DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fipi and DIP-epsilon

DIOPT Version :9

Sequence 1:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	419	Identity:	85/419 - (20%)
Similarity:	168/419 - (40%)	Gaps:	91/419 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLIGFILNLAALTAVAWANHHESLSLSPAEHSVVRYTNESLIVQCRSPDPKVEL-HWKSPKGEI 64
            ::|...:.||.:. .|||.:..:|..|:...|.:.|             :|::.: |.|..|
  Fly    69 VKLACSVKNLGSY-KVAWMHFEQSAILTVHNHVITR-------------NPRISVTHDKHDK--- 116

  Fly    65 IREHK-GRIHIEQTSTEQLKIVFAHIALADKGNWSCEAADGSLHSKS----FDLIVYQKITFTEN 124
               |: ..:||.....|            |:|.:.|:.  .::.:|:    ..::|...|.....
  Fly   117 ---HRTWFLHINNVQEE------------DRGRYMCQI--NTVTAKTQYGFVKVVVPPNIDDALT 164

  Fly   125 ATVMTVKEGEKATILCEVKGEPQPNVTWHFNGQPISAGAADDSKFRIL----------ADGLLIN 179
            ::.:.|:||:..|:.|:.||.|:|.:.|          ..||....::          .|.|.:.
  Fly   165 SSDIIVREGDNVTLRCKAKGSPEPTIKW----------KRDDGNKIVINKTLEVHDLETDSLELE 219

  Fly   180 KVTQNDTGEYACRAYQVNSIASDMQERTVLMKIEHKP-IWSKTPFVSLKYAYINGTATLMCEALA 243
            ::::...|.|.|.|  .|.:...:.:| :.:.::..| :|.....|.:...:   ..||.|...|
  Fly   220 RISRLHMGAYLCIA--SNGVPPSVSKR-IKVSVDFSPMVWIPHQLVGIPIGF---NITLECFIEA 278

  Fly   244 EPPANFTWYRKHNKLHSNNRLYTIQS----DSYWSS--LTIHVLNTSAFDNYRCRARNDLGTIER 302
            .|.:...|.|:::::.:.:..|..::    .||.::  |||..:.:|.:.||:|.|:|..|.::.
  Fly   279 NPTSLNYWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDG 343

  Fly   303 TTRLEQGEKP---PSPANFQLRGFNSNTFDVVL----SAP----------RGPPDSPMGVNGFRI 350
            ..:|.....|   |.|....||...:...::.|    :.|          .||.:|.:......|
  Fly   344 NIKLYMSSPPTTQPPPTTTTLRRTTTTAAEIALDGYINTPLNGNGIGIVGEGPTNSVIASGKSSI 408

  Fly   351 EYMTEM-EFKTDAGKWTNARRKDYAFEEG 378
            :|::.: |......|.|.:..|.:.:.:|
  Fly   409 KYLSNLNEIDKSKQKLTGSSPKGFDWSKG 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	13/87 (15%)
		I-set	128..202	CDD:254352	19/83 (23%)
		Ig	133..>193	CDD:299845	15/69 (22%)
		IG_like	228..307	CDD:214653	20/84 (24%)
		Ig	235..305	CDD:143165	20/75 (27%)
		FN3	312..415	CDD:238020	17/85 (20%)
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	22/119 (18%)
		Ig	69..139	CDD:143165	21/101 (21%)
		IG_like	165..249	CDD:214653	20/96 (21%)
		IGc2	172..237	CDD:197706	18/76 (24%)
		IG_like	267..348	CDD:214653	20/83 (24%)
		Ig	270..339	CDD:299845	19/68 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442835
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840