DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fipi and DIP-delta

DIOPT Version :9

Sequence 1:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	375	Identity:	87/375 - (23%)
Similarity:	147/375 - (39%)	Gaps:	97/375 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FILNLAALTAVAWANHHESLSLSPAEHSVVRYTNE---------SLIVQCRSPDPKVELHWKSPK 61
            |||.:..|..:|       |::.|:     |:||.         :|:......:|:    :..|.
  Fly     2 FILTVVKLLLIA-------LNIFPS-----RFTNRRIMFLIYMTNLVTHVMMDEPR----FAQPI 50

  Fly    62 GEI------------IREHKGR-----IHIEQ-------------------TSTEQLKIVFAHIA 90
            ..:            :.||.|.     |||::                   |.|:...::  |:.
  Fly    51 PNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVISRIPRYSITYTDNTWLL--HVN 113

  Fly    91 LA---DKGNWSCEAADGSLHSKSFDLIVYQKITFTEN-------ATVMTVKEGEKATILCEVKGE 145
            .|   |:|.:.|:.....:.|:    :.|.::....|       .:.:.|:|.:...:.|...|.
  Fly   114 QAHQDDRGYYMCQVNTNPMISQ----VGYLQVVVPPNILDIESTPSSVAVRENQNINMTCRADGF 174

  Fly   146 PQPNVTW-HFNGQPISAGAADDSKFRIL---ADGLLINKVTQNDTGEYACRAYQVNSIASDMQER 206
            |.|.:.| ..:|:.|    |.:.|.::|   ||.|.:.||::|:.|.|.|.|  .|.:...:.:|
  Fly   175 PAPKIIWRREDGEEI----AVEKKKKVLVYDADVLPLTKVSRNEMGAYLCIA--TNGVPPSVSKR 233

  Fly   207 TVLMKIEHKP-IWSKTPFVSLKYAYINGT-ATLMCEALAEPPANFTW-YRKHNKLHSNNRLYTIQ 268
             :::.:|..| ||.....|...    :|| .|:.|...|.|.|...| |.....|.|........
  Fly   234 -IILDVEFSPMIWVPNQLVGAP----SGTDVTIDCHTEAHPKAIIYWVYNSVMVLPSKKYKTDYT 293

  Fly   269 SDSYWS--SLTIHVLNTSAFDNYRCRARNDLGTIERTTRLEQGEKPPSPA 316
            .:||.:  .|||..|....|.||||.::|.||..|.:.|:.:...|.:|:
  Fly   294 ENSYRAHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVYEIPLPSTPS 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	20/129 (16%)
		I-set	128..202	CDD:254352	23/77 (30%)
		Ig	133..>193	CDD:299845	19/63 (30%)
		IG_like	228..307	CDD:214653	27/82 (33%)
		Ig	235..305	CDD:143165	24/72 (33%)
		FN3	312..415	CDD:238020	2/5 (40%)
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	15/97 (15%)
		Ig	145..238	CDD:416386	25/99 (25%)
		Ig strand A	145..149	CDD:409353	1/3 (33%)
		Ig strand A'	154..159	CDD:409353	0/4 (0%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	1/4 (25%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	2/5 (40%)
		Ig strand F	216..223	CDD:409353	4/8 (50%)
		Ig strand G	230..238	CDD:409353	1/8 (13%)
		Ig	242..333	CDD:416386	30/94 (32%)
		Ig strand A'	250..253	CDD:409353	1/2 (50%)
		Ig strand B	259..266	CDD:409353	2/6 (33%)
		Ig strand C	272..277	CDD:409353	1/4 (25%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	0/3 (0%)
		Ig strand E	295..305	CDD:409353	3/9 (33%)
		Ig strand F	314..322	CDD:409353	4/7 (57%)
		Ig strand G	325..334	CDD:409353	3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910