Protein Alignment fipi and NCAM2

DIOPT Version :10

• Sequence 1: NP_787975.1
• Gene: fipi / 33676
• FlyBaseID: FBgn0031627
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: XP_011527877.1
• Gene: NCAM2 / 4685
• HGNCID: 7657
• Length: 874
• Species: Homo sapiens
• Alignment Length: 612
• Identity: 128/612 - (20%)
• Similarity: 198/612 - (32%)
• Gaps: 239/612 - (39%)

  Fly    24 SLSLSPAEHSVVRYTNESLIVQCRSPDPKVELHWKSPKGEIIREHKGRIHIEQTSTEQLKIVFAH 88
            ::|||..|.||    .||....|.:......:.|.:|:||.|...:..:..::....:|.|..|:
Human    49 TISLSKVELSV----GESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNAN 109

  Fly    89 IALADKGNWSCEAAD--GSLHSKSFDLIVYQKITFTENATVMTVKEGEKATILCEVKGEPQPNVT 151
            |  .|.|.:.|:|.|  |.....:..|.:|||:||.|..:....|:||.|.::|.|...|.|.|:
Human   110 I--EDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVS 172

  Fly   152 WHFNGQPISAGAADDSKFRILADG----LLINK-------------------------------- 180
            |.::.:.::  ...|::|.:||:.    |.|||
Human   173 WLYHNEEVT--TISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPA 235

  Fly   181 ------------------------------------------------------------VTQND 185
                                                                        :..:|
Human   236 ISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSD 300

  Fly   186 TGEYACRAYQVNSIASDMQERTVLMKIEHKPIWSKTPFVSLK--YAYINGTATLMCEALAEPPAN 248
            .|.|.|||  .|....|  |:...:::..:|     ..:.||  ..|.||..||:|:|..||...
Human   301 GGPYVCRA--TNKAGED--EKQAFLQVFVQP-----HIIQLKNETTYENGQVTLVCDAEGEPIPE 356

  Fly   249 FTWYR----------------------KH--NKLH------------------------------ 259
            .||.|                      :|  :.||
Human   357 ITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLD 421

  Fly   260 --------SNNRLY--------TIQSD--------SYW--SSLTIHVLNT--------------- 283
                    ||..:|        .|..|        .:|  ..|.:...||
Human   422 IEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILE 486

  Fly   284 ------SAFDNYRCRARNDLGTIERTTRLEQGEKPPSPANFQLRGFNSNTFDVVLSAPRGPPDSP 342
                  :.|..|.|.|.|.:||..:...|...:.|.||...::...:..|..|..:    .|||.
Human   487 IAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFN----KPDSH 547

  Fly   343 MGVNGFRIEYMTEMEFKTDAGK-WTNARRKDYAFEEGATFLLTNLEPDTVYLVRAASRNLAGFSD 406
            .||   .|.:. :::.|..|.: |...|.....    ...:|.||||:|.|.:|.|:.|..|..|
Human   548 GGV---PIHHY-QVDVKEVASEIWKIVRSHGVQ----TMVVLNNLEPNTTYEIRVAAVNGKGQGD 604

  Fly   407 FTKVEKYKTL--------SLEPRVSSG 425
            ::|:|.::||        |:..:.|||
Human   605 YSKIEIFQTLPVREPSPPSIHGQPSSG 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	21/83 (25%)
		IgI_Twitchin_like	120..208	CDD:409541	30/183 (16%)
		Ig strand A	120..123	CDD:409541	2/2 (100%)
		Ig strand A'	127..131	CDD:409541	0/3 (0%)
		Ig strand B	134..141	CDD:409541	2/6 (33%)
		Ig strand C	149..154	CDD:409541	2/4 (50%)
		Ig strand C'	156..159	CDD:409541	0/2 (0%)
		Ig strand D	165..170	CDD:409541	1/4 (25%)
		Ig strand E	173..178	CDD:409541	2/8 (25%)
		Ig strand F	187..195	CDD:409541	5/7 (71%)
		Ig strand G	198..208	CDD:409541	2/9 (22%)
		IG_like	228..307	CDD:214653	31/179 (17%)
		Ig strand B	235..239	CDD:409353	2/3 (67%)
		Ig strand C	248..252	CDD:409353	1/3 (33%)
		Ig strand E	274..278	CDD:409353	1/3 (33%)
		Ig strand F	288..293	CDD:409353	2/4 (50%)
		FN3	312..415	CDD:238020	29/103 (28%)
NCAM2	XP_011527877.1	IgI_1_NCAM-2	46..138	CDD:409452	25/94 (27%)
		Ig strand A	46..51	CDD:409452	0/1 (0%)
		Ig strand A'	54..58	CDD:409452	1/3 (33%)
		Ig strand B	60..70	CDD:409452	3/9 (33%)
		Ig strand C	74..80	CDD:409452	1/5 (20%)
		Ig strand C'	83..85	CDD:409452	1/1 (100%)
		Ig strand D	91..97	CDD:409452	0/5 (0%)
		Ig strand E	99..107	CDD:409452	2/7 (29%)
		Ig strand F	114..121	CDD:409452	2/6 (33%)
		Ig strand G	126..137	CDD:409452	1/10 (10%)
		Ig	142..218	CDD:472250	20/77 (26%)
		Ig strand C	170..174	CDD:409353	1/3 (33%)
		Ig strand E	193..197	CDD:409353	0/3 (0%)
		IgI_1_MuSK	234..323	CDD:409562	9/92 (10%)
		Ig strand A	234..237	CDD:409562	0/2 (0%)
		Ig strand A'	242..247	CDD:409562	0/4 (0%)
		Ig strand B	253..260	CDD:409562	0/6 (0%)
		Ig strand C	266..271	CDD:409562	0/4 (0%)
		Ig strand C'	273..275	CDD:409562	0/1 (0%)
		Ig strand D	282..285	CDD:409562	0/2 (0%)
		Ig strand E	289..295	CDD:409562	0/5 (0%)
		Ig strand F	302..309	CDD:409562	5/8 (63%)
		Ig strand G	315..323	CDD:409562	2/9 (22%)
		IgI_NCAM-2	325..422	CDD:143278	18/101 (18%)
		Ig strand A	325..330	CDD:143278	1/9 (11%)
		Ig strand A'	334..338	CDD:143278	0/3 (0%)
		Ig strand B	342..350	CDD:143278	3/7 (43%)
		Ig strand C	356..362	CDD:143278	2/5 (40%)
		Ig strand C'	365..368	CDD:143278	0/2 (0%)
		Ig strand D	378..384	CDD:143278	0/5 (0%)
		Ig strand E	387..393	CDD:143278	2/5 (40%)
		Ig strand F	401..409	CDD:143278	0/7 (0%)
		Ig strand G	412..422	CDD:143278	0/9 (0%)
		Ig_3	426..504	CDD:464046	13/77 (17%)
		FN3	521..613	CDD:238020	29/103 (28%)
		fn3	619..703	CDD:394996	4/13 (31%)