DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fipi and Opcml

DIOPT Version :9

Sequence 1:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_006510497.1	Gene:	Opcml / 330908	MGIID:	97397	Length:	354	Species:	Mus musculus

Alignment Length:	336	Identity:	84/336 - (25%)
Similarity:	130/336 - (38%)	Gaps:	69/336 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LTAVAWANHHESLSLSPAEHSVVRYT-NESLIVQCRSPDPKVELHWKSPKGEIIREHKGRIHIEQ 76
            :|.|||.|           .|.:.|. |:..     |.||:|                  |.:..
Mouse    63 VTRVAWLN-----------RSTILYAGNDKW-----SIDPRV------------------IILVN 93

  Fly    77 TSTEQLKIVFAHIALADKGNWSCEA-ADGSLHSKSFDLIVYQKITFTENATVMTVKEGEKATILC 140
            |.| |..|:..::.:.|:|.::|.. .|....:....|||.........::.:||.||...|:||
Mouse    94 TPT-QYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLC 157

  Fly   141 EVKGEPQPNVTWHFNGQPISAGAADDSKFRILADGLLINKVTQNDTGEYACRAYQVNSIASDMQE 205
            ...|.|:|.|||.........|...:.::      |.|:.:.::.:|||.|.|  :|.:|:. ..
Mouse   158 LAIGRPEPTVTWRHLSVKEGQGFVSEDEY------LEISDIKRDQSGEYECSA--LNDVAAP-DV 213

  Fly   206 RTVLMKIEHKPIWSKTPFVSLKYAYINGTATLMCEALAEPPANFTWYRKHNKLHSNNRLYTIQSD 270
            |.|.:.:.:.|..||.....:.   :.....|.|||.|.|.|.|.|:::..:|.:......|::.
Mouse   214 RKVKITVNYPPYISKAKNTGVS---VGQKGILSCEASAVPMAEFQWFKEDTRLATGLDGVRIENK 275

  Fly   271 SYWSSLTIHVLNTSAFDNYRCRARNDLGTIERTTRLEQGEKPPSPANFQLRGFNSNTFDVVLSAP 335
            ...|:||...::...:.||.|.|.|.||....:..|.  |..||                  ||.
Mouse   276 GRISTLTFFNVSEKDYGNYTCVATNKLGNTNASITLY--EISPS------------------SAV 320

  Fly   336 RGPPDSPMGVN 346
            .||.....|||
Mouse   321 AGPGAVIDGVN 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	17/83 (20%)
		I-set	128..202	CDD:254352	23/73 (32%)
		Ig	133..>193	CDD:299845	17/59 (29%)
		IG_like	228..307	CDD:214653	21/78 (27%)
		Ig	235..305	CDD:143165	21/69 (30%)
		FN3	312..415	CDD:238020	9/35 (26%)
Opcml	XP_006510497.1	Ig	44..132	CDD:416386	22/103 (21%)
		Ig strand A'	44..49	CDD:409353
		Ig strand B	51..59	CDD:409353
		CDR1	59..63	CDD:409353	84/336 (25%)
		FR2	64..70	CDD:409353	4/5 (80%)
		Ig strand C	64..70	CDD:409353	4/5 (80%)
		CDR2	71..83	CDD:409353	3/16 (19%)
		Ig strand C'	72..76	CDD:409353	1/3 (33%)
		Ig strand C'	80..83	CDD:409353	0/7 (0%)
		FR3	84..118	CDD:409353	11/52 (21%)
		Ig strand D	87..94	CDD:409353	2/24 (8%)
		Ig strand E	97..103	CDD:409353	2/5 (40%)
		Ig strand F	110..118	CDD:409353	2/7 (29%)
		CDR3	119..123	CDD:409353	1/3 (33%)
		Ig strand G	123..132	CDD:409353	1/8 (13%)
		FR4	125..132	CDD:409353	1/6 (17%)
		Ig_3	135..206	CDD:404760	21/78 (27%)
		Ig strand A	135..138	CDD:409353	0/2 (0%)
		Ig strand A'	144..148	CDD:409353	1/3 (33%)
		Ig strand B	151..160	CDD:409353	3/8 (38%)
		Ig strand C	165..170	CDD:409353	3/4 (75%)
		Ig strand C'	171..174	CDD:409353	0/2 (0%)
		Ig strand F	198..206	CDD:409353	5/9 (56%)
		Ig_3	223..300	CDD:404760	21/79 (27%)
		putative Ig strand A	224..230	CDD:409353	3/5 (60%)
		Ig strand B	240..244	CDD:409353	1/3 (33%)
		Ig strand C	253..257	CDD:409353	1/3 (33%)
		Ig strand E	279..283	CDD:409353	2/3 (67%)
		Ig strand F	293..298	CDD:409353	3/4 (75%)
		Ig strand G	306..309	CDD:409353	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740