DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fipi and Igsf9b

DIOPT Version :9

Sequence 1:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001363879.1	Gene:	Igsf9b / 315510	RGDID:	1564717	Length:	1441	Species:	Rattus norvegicus

Alignment Length:	443	Identity:	97/443 - (21%)
Similarity:	159/443 - (35%)	Gaps:	104/443 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LSPAEHSVVRYTNESLIVQCRSPDPKVEL----HWKSPKGEIIREHKGRIHIEQTSTEQLKIVFA 87
            :||.|:..|..:.::|:. ||:......|    :|:........:.|.|:.|....|    ::..
  Rat   232 VSPPENITVNISQDALLT-CRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGT----LIIF 291

  Fly    88 HIALADKGNWSCEAAD--GSLHSKSFDLIVYQKITFTENATVMTVKEGEKATILCEVKGEPQPNV 150
            .:...|.|.::|..::  |...|.|..|.|...........|:.|..|....|.|.|..||...|
  Rat   292 RVKPEDAGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATV 356

  Fly   151 T-WHFNGQPISAGAADDSKFRILADG-LLINKVTQNDTGEYACRAYQVNSIASDMQERTVLMKIE 213
            . |:.:|:|:.  ...:..:.::.|| :.|.:.|:...|.|.|..|  |::.:..|.....:.::
  Rat   357 VKWNKDGRPLQ--VEKNLGWTLMEDGSIRIEEATEEALGTYTCVPY--NTLGTMGQSAPARLVLK 417

  Fly   214 HKPIWSKTPFVSLKYAYINGTATLM-CEALAEPPANFTWYR-------KHNKLHSNNRLYTIQSD 270
            ..|.::..|  ..:|....|...|: |.|..:|....||.:       |||.|.|
  Rat   418 DPPYFTVLP--GWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHNALPS---------- 470

  Fly   271 SYWSSLTIHVLNTSAFDNYRCRARNDLGTIERTTRLEQ-GEKPPSPANFQLR------------- 321
               .||....|:......:.|.|.|.:.:|..:|.|.. |..|.:|.:.::.
  Rat   471 ---GSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVHVSMTTANVSWEPG 532

  Fly   322 --GFNSNTFDV-----VLSAPRGPPD-----SPMGVNGFRIEYMTEMEFKTDAGKWTNARRKDYA 374
              |....||.|     :..|..||.|     .|:|.:                  |
  Rat   533 YDGGYEQTFSVWYGPLMKRAQFGPHDWLSLSVPLGPS------------------W--------- 570

  Fly   375 FEEGATFLLTNLEPDTVYLVRAASRNLAGFSDFTKVEKYKTLSL-----EPRV 422
                  .|:.:|||:|.|.....::|..|.|.|::|....||:.     ||.|
  Rat   571 ------LLVDSLEPETAYQFSVLAQNRLGTSAFSEVVTVNTLAFPVTTPEPLV 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	17/87 (20%)
		I-set	128..202	CDD:254352	20/75 (27%)
		Ig	133..>193	CDD:299845	17/61 (28%)
		IG_like	228..307	CDD:214653	21/86 (24%)
		Ig	235..305	CDD:143165	18/77 (23%)
		FN3	312..415	CDD:238020	24/127 (19%)
Igsf9b	NP_001363879.1	PHA03247	<898..1246	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1044
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1111..1332
		Ig	41..115	CDD:319273
		I-set	139..225	CDD:369462
		Ig	229..321	CDD:386229	20/93 (22%)
		Ig	<353..414	CDD:386229	14/64 (22%)
		Ig	438..502	CDD:319273	18/76 (24%)
		FN3	510..605	CDD:238020	24/127 (19%)
		FN3	621..703	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..821
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000