DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fipi and Fas2

DIOPT Version :9

Sequence 1:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	456	Identity:	104/456 - (22%)
Similarity:	191/456 - (41%)	Gaps:	74/456 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LSLSPAEHSVVRYTNESLIVQCRS--PDPKV--ELHWKSPKGE-IIREHKGR----IHIEQTSTE 80
            |.:.|.:....:...:.||:.||.  |:|.:  :|.||..:.. |:.:..||    ::.|....|
  Fly    33 LEIYPKQEVQRKPVGKPLILTCRPTVPEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGE 97

  Fly    81 QLKIVFAHIALADKGNWSCEA--ADGSLHSKSFDLIVYQKITFTENATVMTVKEGEKATILCEVK 143
            .|.::...:::...|.:.|.|  |:..:..|...:..|..||:|..........|:...::||||
  Fly    98 SLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMCEVK 162

  Fly   144 GEPQPNVTWHFNGQPISAGAADDSKFRILADGLLINKVTQNDTGEYACRAYQVNSIASDMQERTV 208
            .:|.|.:.|..||.||   ...:.|:.:..:||||..|.::|.|.|.|||..:.:  .::.|||:
  Fly   163 ADPNPTIDWLRNGDPI---RTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAVIET--GELLERTI 222

  Fly   209 LMKIEHKPIWSKTPFVSL--KYAYINGTA-TLMCEALAEPPANFTWYRKHNKLH--SNNRLYTIQ 268
            .:::..:|     ..:||  ....:.|.. ...|.|..:|....:|.|...:|:  :.:|   .|
  Fly   223 RVEVFIQP-----EIISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDATQLNVATADR---FQ 279

  Fly   269 SDSYWSSLTIHVLNTSAFDNYRCRARNDLGTIERTTRLEQGEKPPSPANFQLRGFNSNTFDVVLS 333
            .:.....:||..::...:..|.|.|:|..|.:::.|:|....:|.....:.:.|..:....:...
  Fly   280 VNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYELYNVTGARTKEIAITCR 344

  Fly   334 APRGPPDSPMGVNGFRIEYMTEMEFKTDAGKWTNARRKD---------YAFEEG---ATFLLTNL 386
            | :|.|...:   .|| .:.|:.|:       ||.::.|         :..|.|   .|..::|.
  Fly   345 A-KGRPAPAI---TFR-RWGTQEEY-------TNGQQDDDPRIILEPNFDEERGESTGTLRISNA 397

  Fly   387 EPDTVYLVRAASRNLAGFSDFTKVEKYKT--LSLE-----------PRVSSGVKETRNM-CVELG 437
            |.....|.:..:||..       .:.|||  :::|           |.|.|..:...|: |:.:|
  Fly   398 ERSDDGLYQCIARNKG-------ADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMG 455

  Fly   438 V 438
            :
  Fly   456 I 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	20/92 (22%)
		I-set	128..202	CDD:254352	24/73 (33%)
		Ig	133..>193	CDD:299845	22/59 (37%)
		IG_like	228..307	CDD:214653	17/81 (21%)
		Ig	235..305	CDD:143165	15/72 (21%)
		FN3	312..415	CDD:238020	21/114 (18%)
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	20/93 (22%)
		IG_like	144..226	CDD:214653	27/86 (31%)
		IGc2	152..209	CDD:197706	22/59 (37%)
		I-set	230..319	CDD:254352	21/96 (22%)
		IGc2	243..309	CDD:197706	15/68 (22%)
		IG_like	330..424	CDD:214653	22/112 (20%)
		IGc2	339..412	CDD:197706	17/84 (20%)
		Ig	447..518	CDD:143165	3/10 (30%)
		fn3	534..611	CDD:278470
		FN3	640..735	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810