DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fipi and Vsig10

DIOPT Version :9

Sequence 1:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001258265.1	Gene:	Vsig10 / 304529	RGDID:	1565800	Length:	564	Species:	Rattus norvegicus

Alignment Length:	393	Identity:	78/393 - (19%)
Similarity:	120/393 - (30%)	Gaps:	138/393 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 AVAWANHHESL-----SLSPAEHSVVRYTNES---LIVQCRSPDPKVELHWKSPKGEIIREHKGR 71
            |||....||::     |||.:...|..|.|:|   .:|...|..|..     :|:..:  |..|.
  Rat    56 AVAIGEVHENVTLRCGSLSGSRGLVTWYRNDSEPAFLVSSNSSLPPA-----APRFSL--EDAGA 113

  Fly    72 IHIEQTSTEQLKIVFAHIALADKGNWSCEAADGSLHSKSFDLIVYQ-------KITFT---ENAT 126
            :.||.            :.|.|.||::|.......|.....|.|..       .|:.|   .|.|
  Rat   114 LRIEA------------LRLEDDGNYTCREVLNETHWFPVQLRVTSGPAHIDVNISATGTLPNGT 166

  Fly   127 VMTVKEGEKATILCEVKGEPQPNVTWHFNGQPISAGAADDSKFRILADGLLINKVTQNDTGEYAC 191
            :...: |.:....|....:|.|.|.|...   ..:..::.....:.|:...:..:::|..|.|.|
  Rat   167 LYAAR-GSQVDFSCCSAAQPPPEVEWWIQ---THSSVSESLGKNLSANSFTLMLMSKNLQGNYTC 227

  Fly   192 RAYQVNSIASDMQERTVLMKIEHKP---------------------------------IWSKTP- 222
            .|   .::.|..|.:.....:.:.|                                 :|::.|
  Rat   228 SA---TNVLSRRQRKVTTELLVYWPPPSAPQCSAGLSPESANLELTCNWDGGYPDPTFLWTEEPG 289

  Fly   223 -----------------------------------------------FVS--LKYAYINGTATLM 238
                                                           ..|  :|...:.|..||.
  Rat   290 GVVVGNSKLQTLSPSQLSEGKKFKCVGSHILGPESGASCVVQISSPLLASRPMKTCLVGGDVTLT 354

  Fly   239 CEAL-AEPPANFTWYRK----HNKLHSNNRLYTIQSDSYWSSLTIHVLNTSAFDN---YRCRARN 295
            |:.. |.|||...|.|.    ...:..::| |.|......||||||  |.|...:   |.|||.|
  Rat   355 CQVEGANPPARIQWLRNLTQPETAIQPSSR-YVITQQGQSSSLTIH--NCSQDQDGGFYFCRAEN 416

  Fly   296 DLG 298
            .:|
  Rat   417 PVG 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	19/84 (23%)
		I-set	128..202	CDD:254352	12/73 (16%)
		Ig	133..>193	CDD:299845	11/59 (19%)
		IG_like	228..307	CDD:214653	27/79 (34%)
		Ig	235..305	CDD:143165	26/72 (36%)
		FN3	312..415	CDD:238020
Vsig10	NP_001258265.1	Ig	60..146	CDD:299845	24/104 (23%)
		IG_like	60..145	CDD:214653	24/103 (23%)
		IG_like	165..246	CDD:214653	15/87 (17%)
		Ig	175..241	CDD:143165	13/71 (18%)
		Ig_3	255..318	CDD:290638	2/62 (3%)
		IG_like	347..429	CDD:214653	27/76 (36%)
		Ig	351..426	CDD:143165	26/72 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100