DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fipi and ncam1a

DIOPT Version :9

Sequence 1:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_009293555.1	Gene:	ncam1a / 30447	ZFINID:	ZDB-GENE-990415-31	Length:	1010	Species:	Danio rerio

Alignment Length:	445	Identity:	106/445 - (23%)
Similarity:	189/445 - (42%)	Gaps:	93/445 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RYT--------NESLIVQCRS---PDPKVELHWKSPKGEIIREHKGRIHIEQTSTEQLKIVFAHI 89
            |||        |:::.:.|.:   |:|.|:  |.....|:..:.|..::.:.:     ::....:
Zfish   214 RYTELNATADINQAVTLACHADGYPEPTVK--WARGNTELESDEKYSLNEDGS-----ELTIKDV 271

  Fly    90 ALADKGNWSCEA---ADGSLHSKSFDLIVYQKITFTENATVMTVKEGEKATILCEVKGEPQPNVT 151
            ...|:|::.|.|   |.......:.::.|..||||.||.|...::  |:.|:.||..|:|.||:.
Zfish   272 NKLDEGDYKCIARNKAGERSEEVTLNVFVQPKITFLENQTASELE--EQITLTCEATGDPTPNII 334

  Fly   152 WHFNGQPIS----AGAADDSKFRILADG------------LLINKVTQNDTGEYACRAYQVNSIA 200
            |.|..:..:    |......|.:.| ||            |.:..|...|.|:|.|.|.  |||.
Zfish   335 WSFGRRVFTENEQASWTRPEKHKSL-DGNVVVRSDARVSSLTLKYVQFTDAGQYLCTAR--NSIG 396

  Fly   201 SDMQERTVLMKIEHKP---------IWSKTPFVSLKYAYINGTATLMCEALAEPPANFTWYRKHN 256
            .|:|  ::.:::.:.|         .|...|            |.:.|||||.|.|:..|:|...
Zfish   397 QDIQ--SMYLEVRYAPKIQGPQAVFTWEGNP------------ANITCEALAHPGASVLWFRDGQ 447

  Fly   257 KLHSNN----RLYTIQSDSYWSSLTIHVLNTSAFDNYRCRARNDLGTIERTTRLEQGEKPPSPAN 317
            :|.|.|    ::|...:.|:   |.:...:.:.|.:|.|.|.|.:||..:...|.|.:.|.:|:.
Zfish   448 QLPSANTTNVKIYNTPTVSF---LEVTPDSQNDFGSYNCTATNVIGTESKEFILVQADVPSAPSI 509

  Fly   318 FQLRGFNSNTFDVVLSAPRGPPDSPMGVNGFRIEYMTEMEFKTDAGK-WTNARRKDYAFEEGATF 381
            .::..: |:|..:....|......|:      ::|..|...   ||: ||:   ::|..|:|...
Zfish   510 ERVEPY-SSTAMIEFEEPASSGGVPV------LKYKAEWRI---AGQDWTD---REYELEDGLNL 561

  Fly   382 L-LTNLEPDTVYLVRAASRNLAGFSDFTKVEKYKT------LSLEPRVSSGVKET 429
            : :..|:|:|.|.|:.::.|..|..:.:..|.:||      ..:.|...:.:..|
Zfish   562 ITIVGLKPETTYEVKISAINGKGEGESSAPESFKTQPVRLPFRMSPETPTSIPPT 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	16/92 (17%)
		I-set	128..202	CDD:254352	25/89 (28%)
		Ig	133..>193	CDD:299845	21/75 (28%)
		IG_like	228..307	CDD:214653	23/82 (28%)
		Ig	235..305	CDD:143165	23/73 (32%)
		FN3	312..415	CDD:238020	23/104 (22%)
ncam1a	XP_009293555.1	Ig	20..112	CDD:299845
		I-set	21..111	CDD:254352
		IG_like	121..200	CDD:214653
		IGc2	128..189	CDD:197706
		Ig	208..301	CDD:299845	16/93 (17%)
		IG_like	219..298	CDD:214653	13/85 (15%)
		Ig	300..406	CDD:299845	35/112 (31%)
		IG_like	308..406	CDD:214653	30/104 (29%)
		ig	413..498	CDD:278476	25/99 (25%)
		IG_like	415..498	CDD:214653	25/97 (26%)
		fn3	505..589	CDD:278470	21/96 (22%)
		FN3	624..715	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.770