DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fipi and Ncam2

DIOPT Version :9

Sequence 1:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_981954.2	Gene:	Ncam2 / 288280	RGDID:	1303131	Length:	837	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	116/495 - (23%)
Similarity:	202/495 - (40%)	Gaps:	117/495 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 AVAWANHHESLSLSPAEHSVVRYTN---------------------------------------- 39
            ||:|..|:|.::..|.....|...|
  Rat   145 AVSWLYHNEEVTTIPDNRFAVLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPP 209

  Fly    40 ----------------ESLIVQCR---SPDPKVELHWKSPKGEIIREHKGRIHIEQTSTEQLKIV 85
                            |.:.:.|:   ||||.:.  | ...|::|.|::..| ::.::||   :.
  Rat   210 AIVMPQKSFNATAERGEEMTLTCKASGSPDPAIS--W-FRNGKLIEENEKYI-LKGSNTE---LT 267

  Fly    86 FAHIALADKGNWSCEAAD--GSLHSKSF-DLIVYQKITFTENATVMTVKEGEKATILCEVKGEPQ 147
            ..:|...|.|::.|:|.:  |....::| .:.|...|...:|.   |..|....|::||.:|||.
  Rat   268 VRNIINKDGGSYVCKATNKAGEDQKQAFLQVFVQPHILQLKNE---TTSENGHVTLICEAEGEPV 329

  Fly   148 PNVTWH--FNGQPISAG-AADDSKFRILA----DGLLINKVTQNDTGEYACRAYQVNSIASDM-- 203
            |.:||.  .:|...|.| .:.|.:..:..    ..|.|..|..:|:|.|.|.|      ||.:
  Rat   330 PEITWKRAIDGVTFSEGDKSPDGRIEVKGQHGRSSLHIRDVKLSDSGRYDCEA------ASRIGG 388

  Fly   204 QERTVLMKIEHKPIWSKTPFVS---LKYAYINGTATLMCEALAEPPANFTWYRKHNKLHSNNRLY 265
            .:|::.:.||:.|     .|||   :.|::......:.|:..|.|||:..|.|:...|.:.|..:
  Rat   389 HQRSMHLDIEYAP-----KFVSNQTMYYSWEGNPINISCDVKANPPASIHWRREKLVLPAKNTTH 448

  Fly   266 TIQSDSYWSSLTIHVLNTS--AFDNYRCRARNDLGTIERTTRLEQGEKPPSPANFQLRGFNSNTF 328
             :::.|....:.:.:..||  .|..|.|.|.|.:||..:...||..:.|.||...::...:..|.
  Rat   449 -LKTHSVGRKMILEIAPTSDNDFGRYNCTATNRIGTRFQEYILELADVPSSPRGVKIIELSQTTA 512

  Fly   329 DVVLSAPRGPPDSPMGVNGFRIEYMTEMEFKTDAGKWTNARRKDYAFEEGATFLLTNLEPDTVYL 393
            .:..:.|......|  ::.:::: :.|:..:|    |...|.....    .|.:|::|||:|.|.
  Rat   513 KISFNKPESHGGVP--IHHYQVD-VKEVTSET----WKIVRSHGVQ----TTVVLSSLEPNTTYE 566

  Fly   394 VRAASRNLAGFSDFTKVEKYKTL--------SLEPRVSSG 425
            ||.|:.|..|..|::|:|.::||        |:..:.|||
  Rat   567 VRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSG 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	22/143 (15%)
		I-set	128..202	CDD:254352	24/80 (30%)
		Ig	133..>193	CDD:299845	20/66 (30%)
		IG_like	228..307	CDD:214653	20/80 (25%)
		Ig	235..305	CDD:143165	19/71 (27%)
		FN3	312..415	CDD:238020	25/102 (25%)
Ncam2	NP_981954.2	IgI_1_NCAM-2	21..113	CDD:409452
		Ig strand B	38..42	CDD:409452
		Ig strand C	50..54	CDD:409452
		Ig strand E	76..80	CDD:409452
		Ig strand F	90..95	CDD:409452
		Ig strand G	104..107	CDD:409452
		IGc2	128..189	CDD:197706	8/43 (19%)
		Ig strand B	130..139	CDD:409353
		Ig strand C	145..153	CDD:409353	4/7 (57%)
		Ig strand C'	156..159	CDD:409353	0/2 (0%)
		Ig strand D	162..167	CDD:409353	1/4 (25%)
		Ig strand E	168..175	CDD:409353	1/6 (17%)
		IgI_1_MuSK	209..298	CDD:409562	20/95 (21%)
		Ig strand B	228..232	CDD:409562	0/3 (0%)
		Ig strand C	241..245	CDD:409562	1/6 (17%)
		Ig strand E	264..268	CDD:409562	2/6 (33%)
		Ig strand F	278..283	CDD:409562	1/4 (25%)
		Ig strand G	291..294	CDD:409562	0/2 (0%)
		Ig	300..397	CDD:416386	29/105 (28%)
		Ig strand A	300..305	CDD:409353	1/4 (25%)
		Ig strand A'	309..313	CDD:409353	2/6 (33%)
		Ig strand B	317..325	CDD:409353	3/7 (43%)
		Ig strand C	331..337	CDD:409353	2/5 (40%)
		Ig strand C'	340..343	CDD:409353	1/2 (50%)
		Ig strand D	353..359	CDD:409353	0/5 (0%)
		Ig strand E	362..368	CDD:409353	1/5 (20%)
		Ig strand F	376..384	CDD:409353	4/13 (31%)
		Ig strand G	387..397	CDD:409353	1/9 (11%)
		Ig_3	401..479	CDD:404760	21/83 (25%)
		Ig strand B	418..422	CDD:409353	0/3 (0%)
		Ig strand C	431..435	CDD:409353	0/3 (0%)
		Ig strand E	458..462	CDD:409353	0/3 (0%)
		Ig strand F	472..477	CDD:409353	2/4 (50%)
		Ig strand G	486..489	CDD:409353	0/2 (0%)
		FN3	496..588	CDD:238020	25/102 (25%)
		fn3	594..678	CDD:394996	4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I10927
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.870