DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fipi and Dscam4

DIOPT Version :9

Sequence 1:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	110/530 - (20%)
Similarity:	186/530 - (35%)	Gaps:	147/530 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ALTAVAWANHHESLSLSPAEH-----SVVRYTNESLIVQCR-SPDPKVELHWKSPKGEIIREHKG 70
            |..|:...:|...:::....:     .:...:...|||:|. :..|..::||:.....:....:.
  Fly   501 AQNAIGKVSHSAKVNIYGLPYIREMPKITGISGSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQ 565

  Fly    71 RIHIEQT-STEQLKIVFAHIALADKGNWSCEAAD----GSLHSKSFDLIVYQKITFTENATVMTV 130
            |.:...| ..|||:      .|.|.|.::|.|.:    .|..:....::|..||...:..|.| :
  Fly   566 RAYNNGTLIIEQLQ------RLEDAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNM-L 623

  Fly   131 KEGEKATILCEV-KGEPQPNVTWHFNGQP-ISAGAADDSKFRILAD---GLLINKVTQNDTGEYA 190
            :||.:|.|.|:: :|:...:..|..||:| |..|   :..||.|.:   .|:|..::.:.:|.|.
  Fly   624 REGMRAAISCQILEGDLPVSFRWERNGKPLIGTG---NEVFRRLDEYSASLVIEHISSDHSGNYT 685

  Fly   191 CRAYQVNSIASDMQERTVLMKIEHKPIW-----------------------SKTPFVSLKYA--- 229
            |.|..|    :..:..||.:.:...|.|                       ..||.::.|.|
  Fly   686 CIASNV----AGTERFTVPLTVNVPPKWILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGP 746

  Fly   230 ----------------YINGT-----------ATLMCEA-------------------------- 241
                            :.|||           ...:|||
  Fly   747 TPGEYKDFLYEPTVQLFPNGTIFFKKISKESQGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKT 811

  Fly   242 -----------------LAEPPANFTWYRKHNKLHSNNRL---YTIQ----SDSYWSSLTIHVLN 282
                             ..:.|.:|.|..:..:.:.:..|   |||:    .|...|.|.|....
  Fly   812 KQISVAKGKQVHVQCNVQGDNPIDFKWKIQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTY 876

  Fly   283 TSAFDNYRCRARNDLGTIERTTRLEQGEKPPSPANFQLRGFNSNTFDVVLSAPRGPPDSPMGVNG 347
            ......|.|:|.|..|..|.:.:|...|.|..|.|.::....|.:..:..|.|.. .:||:.
  Fly   877 RQDTGIYICQASNAFGQDEMSIQLIVQEVPEQPKNLRINSQQSRSLQLTWSQPFA-GNSPIE--- 937

  Fly   348 FRIEYMTEMEFKTDAGKWTNARRKDYAFEEGATFLLT--NLEPDTVYLVRAASRNLAGFSDFTKV 410
               ||  .:.:|..:..|.||.....|   ||..::.  .|.|...|.:|.::.|..|.|:|::|
  Fly   938 ---EY--HIYYKQISDIWQNAEHLTIA---GAQTVINIQQLRPAKAYHIRMSAENKLGASEFSEV 994

  Fly   411 EKYKTLSLEP 420
            .:..||...|
  Fly   995 VQVTTLEEVP 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	18/87 (21%)
		I-set	128..202	CDD:254352	23/78 (29%)
		Ig	133..>193	CDD:299845	19/64 (30%)
		IG_like	228..307	CDD:214653	24/158 (15%)
		Ig	235..305	CDD:143165	20/119 (17%)
		FN3	312..415	CDD:238020	26/104 (25%)
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386
		Ig strand A	235..238	CDD:409353
		Ig strand A'	244..248	CDD:409353
		Ig strand B	251..258	CDD:409353
		Ig strand C	266..271	CDD:409353
		Ig strand C'	276..279	CDD:409353
		Ig strand D	285..289	CDD:409353
		Ig strand E	292..298	CDD:409353
		Ig strand F	305..313	CDD:409353
		Ig strand G	316..326	CDD:409353
		IgC2_3_Dscam	329..417	CDD:409549
		Ig strand B	347..351	CDD:409549
		Ig strand C	360..364	CDD:409549
		Ig strand E	383..387	CDD:409549
		Ig strand F	397..402	CDD:409549
		Ig strand G	410..413	CDD:409549
		IgI_4_Dscam	422..516	CDD:409548	3/14 (21%)
		Ig strand B	439..443	CDD:409548
		Ig strand C	452..456	CDD:409548
		Ig strand E	482..486	CDD:409548
		Ig strand F	496..501	CDD:409548	110/530 (21%)
		Ig strand G	509..512	CDD:409548	1/2 (50%)
		IgI_5_Dscam	520..607	CDD:409550	18/92 (20%)
		Ig strand B	536..540	CDD:409550	3/3 (100%)
		Ig strand C	549..553	CDD:409550	1/3 (33%)
		Ig strand E	571..575	CDD:409550	1/3 (33%)
		Ig strand F	586..591	CDD:409550	1/4 (25%)
		Ig strand G	600..603	CDD:409550	0/2 (0%)
		Ig	610..703	CDD:416386	28/100 (28%)
		Ig strand A	611..613	CDD:409353	0/1 (0%)
		Ig strand A'	620..624	CDD:409353	2/4 (50%)
		Ig strand B	627..636	CDD:409353	3/8 (38%)
		Ig strand C	641..648	CDD:409353	1/6 (17%)
		Ig strand C'	650..652	CDD:409353	1/1 (100%)
		Ig strand D	659..664	CDD:409353	2/4 (50%)
		Ig strand E	668..675	CDD:409353	2/6 (33%)
		Ig strand F	682..690	CDD:409353	4/7 (57%)
		Ig strand G	693..702	CDD:409353	2/8 (25%)
		IgI_7_Dscam	706..801	CDD:409546	12/94 (13%)
		Ig strand B	724..728	CDD:409546	0/3 (0%)
		Ig strand C	737..741	CDD:409546	0/3 (0%)
		Ig strand E	766..770	CDD:409546	2/3 (67%)
		Ig strand F	780..785	CDD:409546	1/4 (25%)
		Ig strand G	794..797	CDD:409546	0/2 (0%)
		Ig	818..904	CDD:416386	18/85 (21%)
		putative Ig strand B	820..827	CDD:409353	0/6 (0%)
		putative Ig strand C	835..841	CDD:409353	2/5 (40%)
		putative Ig strand C'	853..856	CDD:409353	0/2 (0%)
		putative Ig strand D	862..866	CDD:409353	1/3 (33%)
		putative Ig strand E	868..874	CDD:409353	3/5 (60%)
		putative Ig strand F	881..889	CDD:409353	3/7 (43%)
		putative Ig strand G	892..902	CDD:409353	3/9 (33%)
		FN3	906..999	CDD:238020	26/104 (25%)
		FN3	1006..1110	CDD:238020
		fn3	1117..1203	CDD:394996
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810