DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fipi and Vsig10

DIOPT Version :9

Sequence 1:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001028483.2	Gene:	Vsig10 / 231668	MGIID:	2448533	Length:	558	Species:	Mus musculus

Alignment Length:	414	Identity:	83/414 - (20%)
Similarity:	132/414 - (31%)	Gaps:	151/414 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LTAVAWANHHESLSL-----SPAEHSVVRYTNES---LIVQCRSPDPKVELHWKSPKGEIIREHK 69
            |.|||....|::::|     |.:...|..|.|:|   .:|...|..|..     :|:..:  |..
Mouse    49 LEAVAIGEVHDNVTLRCGSASGSRGLVTWYRNDSEPAFLVSFNSSLPPA-----APRFSL--EDA 106

  Fly    70 GRIHIEQTSTEQLKIVFAHIALADKGNWSCEAADGSLHSKSFDLIV-----YQKITFTENATV-- 127
            |.:.||.            :.|.|.||::|:......|.....|.|     |.::..:...|:
Mouse   107 GALRIEA------------LRLEDDGNYTCQEVLNETHWFPVRLRVASGPAYVEVNISATGTLPN 159

  Fly   128 --MTVKEGEKATILCEVKGEPQPNVTW--------HFNGQPISAGAADDSKFRILADGLLINKVT 182
              :....|.:....|....:|.|.|.|        .|.|:.:||     :.|.::.       ::
Mouse   160 GTLYAARGSQVDFNCCSAAQPPPEVEWWIQTHSIPEFLGKNLSA-----NSFTLML-------MS 212

  Fly   183 QNDTGEYACRAYQVNSIASDMQERTVLMKIEHKP------------------------------- 216
            ||..|.|.|.|   .::.|..|.:.....:.:.|
Mouse   213 QNLQGNYTCSA---TNVLSGRQRKVTTELLVYWPPPSAPQCSVEVSSESTTLELACNWDGGYPDP 274

  Fly   217 --IWSKTP----------------------------------------FVSL----------KYA 229
              :|::.|                                        .|.|          :..
Mouse   275 TFLWTEEPGGTIMGNSKLQTLSPAQLLEGKKFKCVGNHILGPESGASCVVKLSSPLLPSQPMRTC 339

  Fly   230 YINGTATLMCEAL-AEPPANFTWYRKHNK---LHSNNRLYTIQSDSYWSSLTIHVLNTSAFDN-Y 289
            ::.|..||.||.. |.|||...|.|...:   ..|::.:.|.|..|  ||||||..:....:. |
Mouse   340 FVGGNVTLTCEVSGANPPARIQWLRNLTQPAIQPSSHYIITQQGQS--SSLTIHNCSQDLDEGFY 402

  Fly   290 RCRARNDLGTIERTTRLEQGEKPP 313
            .|:|.|.:|.  |.|.:....|.|
Mouse   403 YCQAENLVGV--RATNIWLSVKEP 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	19/84 (23%)
		I-set	128..202	CDD:254352	17/81 (21%)
		Ig	133..>193	CDD:299845	16/67 (24%)
		IG_like	228..307	CDD:214653	28/83 (34%)
		Ig	235..305	CDD:143165	26/74 (35%)
		FN3	312..415	CDD:238020	1/2 (50%)
Vsig10	NP_001028483.2	Ig	47..135	CDD:299845	25/104 (24%)
		IG_like	55..140	CDD:214653	22/103 (21%)
		IG_like	160..240	CDD:214653	19/94 (20%)
		Ig	<184..238	CDD:299845	15/68 (22%)
		IG_like	341..421	CDD:214653	28/83 (34%)
		Ig	345..418	CDD:143165	27/76 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..515
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..558
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100