DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fipi and Ncam1

DIOPT Version :9

Sequence 1:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_006510118.1	Gene:	Ncam1 / 17967	MGIID:	97281	Length:	1162	Species:	Mus musculus

Alignment Length:	423	Identity:	113/423 - (26%)
Similarity:	181/423 - (42%)	Gaps:	69/423 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 AEHSVVRYT---NESLIVQCRS---PDPKVELHWKSPKGEII--REHKGRIHIEQTSTEQLKIVF 86
            |..|:|..|   .:|:.:.|.:   |:|  .:.| :..||.|  .|.....||....:.:|.|
Mouse   216 ARQSIVNATANLGQSVTLVCDADGFPEP--TMSW-TKDGEPIENEEEDDEKHIFSDDSSELTI-- 275

  Fly    87 AHIALADKGNWSCEA------ADGSLHSKSFDLIVYQKITFTENATVMTVKEGEKATILCEVKGE 145
            .::...|:..:.|.|      .|.|:|.|.|   ...|||:.||.|.|.::  |:.|:.||..|:
Mouse   276 RNVDKNDEAEYVCIAENKAGEQDASIHLKVF---AKPKITYVENQTAMELE--EQVTLTCEASGD 335

  Fly   146 PQPNVTWHFNGQPIS----AGAADDSKFRILADG------------LLINKVTQNDTGEYACRAY 194
            |.|::||..:.:.||    |......|...| ||            |.:..:...|.|||.|.|
Mouse   336 PIPSITWRTSTRNISSEEKASWTRPEKQETL-DGHMVVRSHARVSSLTLKSIQYTDAGEYICTA- 398

  Fly   195 QVNSIASDMQERTVLMKIEHKPIWSKTPFVSLKYAYINGTATLMCEALAEPPANFTWYRKHNKL- 258
             .|:|..|.|  ::.:::::.|   |.......|.:......:.||..|.|.|..:|:|....|
Mouse   399 -SNTIGQDSQ--SMYLEVQYAP---KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 457

  Fly   259 ---HSNNRLYTIQSDSYWSSLTIHVLNTSAFDNYRCRARNDLGTIERTTRLEQGEKPPSPANFQL 320
               :||.::|...|.||   |.:...:.:.|.||.|.|.|.:|.......|.|.:.|.||:..::
Mouse   458 SSNYSNIKIYNTPSASY---LEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDRV 519

  Fly   321 RGFNSNTFDVVLSAPRGPPDSPMGVNGFRIEYMTEMEFKTDAG---KWTNARRKDYAFEEGATFL 382
            ..: |:|..|....|......|:      ::|..|.:...:..   ||.:|:.   |..||...:
Mouse   520 EPY-SSTAQVQFDEPEATGGVPI------LKYKAEWKSLGEESWHFKWYDAKE---ANMEGIVTI 574

  Fly   383 LTNLEPDTVYLVRAASRNLAGFSDFTKVEKYKT 415
            : .|:|:|.|.||.|:.|..|..:.:...::||
Mouse   575 M-GLKPETRYSVRLAALNGKGLGEISAATEFKT 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	24/95 (25%)
		I-set	128..202	CDD:254352	26/89 (29%)
		Ig	133..>193	CDD:299845	22/75 (29%)
		IG_like	228..307	CDD:214653	23/82 (28%)
		Ig	235..305	CDD:143165	22/73 (30%)
		FN3	312..415	CDD:238020	25/105 (24%)
Ncam1	XP_006510118.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652
		Ig3_NCAM-1_like	211..308	CDD:143207	25/99 (25%)
		Ig_NCAM-1	307..413	CDD:143277	34/112 (30%)
		Ig_3	417..494	CDD:372822	23/82 (28%)
		FN3	509..606	CDD:238020	25/107 (23%)
		fn3	649..731	CDD:365830
		PHA03247	<905..1140	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11169
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.870