DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fipi and Kirrel

DIOPT Version :9

Sequence 1:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_011238330.1	Gene:	Kirrel / 170643	MGIID:	1891396	Length:	805	Species:	Mus musculus

Alignment Length:	344	Identity:	82/344 - (23%)
Similarity:	128/344 - (37%)	Gaps:	73/344 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LSLSPAEHSVVRYTNESLIVQCRSPDPKVELHWKSPKG-----EIIREHKGRIHIE---QTSTEQ 81
            |.:.|.:..:.|      :..|||.:..:      |.|     |:...|...:.:.   ||..|.
Mouse   217 LLIEPTDLDIGR------VFTCRSMNEAI------PNGKETSIELDVHHPPTVTLSIEPQTVLEG 269

  Fly    82 LKIVFAHIALAD---------KGNWSCEAADGSLHSKSFDLI---------VYQKITFTENATVM 128
            .:::|...|.|:         ||.:..|.|..|.:..:.|..         ||.|:..|..:|::
Mouse   270 ERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVYNKVGSTNVSTLV 334

  Fly   129 ---------------TVKEGEKATILCEVKGEPQPNVTW---HFNGQPISAGAADDSKF--RILA 173
                           |...|...|:.|...|.|...:||   ..|..|...|:..::..  ::|:
Mouse   335 NVHFAPRIVVYPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRLPGSPPEANLSAQVLS 399

  Fly   174 DG--LLINKVTQNDTGEYACRAYQVNSIASDMQERTVLMKIEHKPIWSKTPFVSLKYAYINGTAT 236
            :.  ||:..|||.|.|.|.|||. |..|.  :.||.|.:.:...||.|..   ::::|.......
Mouse   400 NSNQLLLKSVTQADAGTYTCRAI-VPRIG--VAEREVPLYVNGPPIISSE---AVQFAVRGDGGK 458

  Fly   237 LMC-EALAEPPANFTWYRKHNKLHSNN-RLYTIQ----SDSYWSSLTI-HVLNTSAFDNYRCRAR 294
            :.| .....||....|..|.|.|.... ..||::    .....|:||| :|:......:|.|.|.
Mouse   459 VECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAW 523

  Fly   295 NDLGTIERTTRLEQGEKPP 313
            |..|......:||:.|..|
Mouse   524 NSFGPGTAIIQLEEREVLP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	20/107 (19%)
		I-set	128..202	CDD:254352	25/95 (26%)
		Ig	133..>193	CDD:299845	20/66 (30%)
		IG_like	228..307	CDD:214653	20/85 (24%)
		Ig	235..305	CDD:143165	19/76 (25%)
		FN3	312..415	CDD:238020	1/2 (50%)
Kirrel	XP_011238330.1	Ig	54..148	CDD:386229
		Ig2_KIRREL3-like	170..251	CDD:143236	9/45 (20%)
		Ig	255..336	CDD:386229	17/80 (21%)
		Ig_3	340..421	CDD:372822	21/80 (26%)
		Ig5_KIRREL3	439..536	CDD:143306	23/99 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900