DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fipi and ncam2

DIOPT Version :9

Sequence 1:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_012811963.1	Gene:	ncam2 / 100151722	XenbaseID:	XB-GENE-1217730	Length:	865	Species:	Xenopus tropicalis

Alignment Length:	404	Identity:	109/404 - (26%)
Similarity:	183/404 - (45%)	Gaps:	58/404 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ESLIVQCR---SPDPKVELHWKSPKGEIIREHKGRIHIEQTSTEQLKIVFAHIALADKGNWSCEA 101
            |.:.:.||   ||.|.:..|   ..|:::.|:: :..:.:.:||   :...:|...|.|.:.|.|
Frog   255 EDITLFCRATGSPKPYITWH---RNGKLVEENE-KYDLREDNTE---LTVKNIISTDSGLYVCRA 312

  Fly   102 AD--GSLHSKSF-DLIVYQKITFTENATVMTVKEGEKATILCEVKGEPQPNVTWHFNGQPISAGA 163
            .:  |....:|| .:.|...|...:|.|  |::.|. .|:.||.:|||.|.:||..:...:....
Frog   313 TNKAGFTEKQSFLQVFVQPHIVQLQNET--TIEHGH-VTLTCEAEGEPIPEITWKRSSDGMIFYD 374

  Fly   164 ADDSK-FRILADG------LLINKVTQNDTGEYACRAYQVNSIASDM--QERTVLMKIEHKPIWS 219
            .|.|: .||.:.|      |.|..|..:|.|.|.|.|      ||.:  .::::.:.||:.|
Frog   375 GDKSQDGRIESTGHHGKSSLHIKSVMLSDAGRYDCEA------ASRIGGHQKSMYLNIEYAP--- 430

  Fly   220 KTPFVS---LKYAYINGTATLMCEALAEPPANFTWYRKHNKLHSNNRLYTIQS--DSYWSSLTIH 279
              .|:|   :.|::.|....:.|:..:.||::..|.|....|.:.| :..|::  |.....|.|.
Frog   431 --KFISNQTIYYSWENNPINISCDVTSNPPSSIYWSRDKLLLPARN-ITNIKTYRDGKRILLEIT 492

  Fly   280 VLNTSAFDNYRCRARNDLGTIERTTRLEQGEKPPSPANFQLRGFN-SNTFDVVLSAPRGPPDSPM 343
            .|:.:.|..|.|.|.|.:|:..:...|...:.|.||  :.||... |.|:..|..   ..|||..
Frog   493 PLSDNDFGRYNCTAINSIGSRIQEYILTLADVPSSP--YGLRVIELSQTYAKVFF---NKPDSHG 552

  Fly   344 GVNGFRIEYMTEMEFKTDAGK-WTNARRKDYAFEEGATFLLTNLEPDTVYLVRAASRNLAGFSDF 407
            ||   .|.:. :|:||..:.: |...|    :.......:|.||:.:|.|.|:.|:.|..|..::
Frog   553 GV---PIHHY-QMDFKEVSSEIWKVVR----SHGTQTIIVLGNLDANTTYEVKVAAVNGKGKGEY 609

  Fly   408 TKVEKYKTLSL-EP 420
            :|.|.::||.: ||
Frog   610 SKTEIFQTLPVREP 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	19/80 (24%)
		I-set	128..202	CDD:254352	25/80 (31%)
		Ig	133..>193	CDD:299845	22/66 (33%)
		IG_like	228..307	CDD:214653	20/80 (25%)
		Ig	235..305	CDD:143165	18/71 (25%)
		FN3	312..415	CDD:238020	30/104 (29%)
ncam2	XP_012811963.1	Ig	50..141	CDD:386229
		IG_like	150..234	CDD:214653
		Ig	237..330	CDD:386229	19/81 (23%)
		Ig	329..426	CDD:386229	30/105 (29%)
		IG_like	442..520	CDD:214653	19/78 (24%)
		FN3	525..617	CDD:238020	30/104 (29%)
		fn3	623..706	CDD:365830	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010