DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3251 and Otud4

DIOPT Version :9

Sequence 1:	NP_608851.1	Gene:	CG3251 / 33671	FlyBaseID:	FBgn0031622	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001242962.1	Gene:	Otud4 / 73945	MGIID:	1098801	Length:	1107	Species:	Mus musculus

Alignment Length:	439	Identity:	123/439 - (28%)
Similarity:	198/439 - (45%)	Gaps:	72/439 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PIDRFLERRQLFRKHMLGDASSLFRVVAEQVYDTQMLHYEVRMECVRYMFTKWKTFRRFVSGDFD 83
            |:|.:|.:..|:||.:..|.|.|||.|||||..:|..|.||||.|:||:....:.|..|:.|.|:
Mouse    24 PMDAYLRKLGLYRKLVAKDGSCLFRAVAEQVLHSQSRHVEVRMACIRYLRENREKFEAFIEGSFE 88

  Fly    84 EYLWHLGKTKTAGTILELGAMCHLYRRNVIIY-EPFDMGRMVTYNKDYKEILRIFMNSMGHFETV 147
            |||..|...:.....:|:.|:..:||::.:|| ||......||.|...:::|..|.|. .|::.|
Mouse    89 EYLKRLENPQEWVGQVEISALSLMYRKDFVIYQEPNVSPSHVTENNFPEKVLLCFSNG-NHYDIV 152

  Fly   148 LTMQDVDMAAVCQSVSFKMLYKHLFRLPDVDLAVEWMLYPDTFKMGTEYEFDSRGRAIRLLCRNG 212
            ..:...|.:|:|||:.:::||:.:|: .||...:..:...:..:.......||...:    |::.
Mouse   153 YPITYKDSSAMCQSLLYELLYEKVFK-TDVSKIMMGLEASEVAEESNSEISDSEDDS----CKSK 212

  Fly   213 RSFKLD----RPESTICLLENSQMCPFHNRRLAMGGQFADFSCMRILLEENNIPFSYLVAKSMDP 273
            .:...|    :|..:    ||    |.:|      |..||            :|.|..|.||::|
Mouse   213 STAATDVNGFKPSGS----EN----PKNN------GNSAD------------LPLSRKVLKSLNP 251

  Fly   274 CRYRNVELTSAIEAR--REAYEFGIYIGDYNFKVGAKC-QVQLDTNRRDLLSACYIQSIDKKKSV 335
            ..|||||....::::  ::..::.|..| ..::||.|| ||:||.|.:  ||...|..:..:..:
Mouse   252 AVYRNVEYEIWLKSKQAQQKRDYSIAAG-LQYEVGDKCHQVRLDHNGK--LSNADIHGVHSENGL 313

  Fly   336 CKVFIEEQGKLVDVPSDNLHPLPPDEFKAWDFARKRPQRLHNSQMGRQSVQGDQQGFVPDPMPGT 400
              |..||.|| ...|. ||.|.||:   :|:....:..:..||.....| ..|.:|
Mouse   314 --VLSEELGK-KHTPK-NLKPPPPE---SWNTVSGKKMKKPNSGQNFHS-DTDYRG--------- 361

  Fly   401 APSMPPPPVADPRPVNVTAQQPPVFGPSRWMEPTRPLMPNPLMIHQTGS 449
                       |:.:|...:.|... |.|...|:..:..:....|.|||
Mouse   362 -----------PKNLNKPIKAPSAL-PPRLQHPSSGVRQHAFSSHSTGS 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3251	NP_608851.1	OTU	36..>115	CDD:303090	31/78 (40%)
Otud4	NP_001242962.1	Cys-loop. /evidence=ECO:0000250\|UniProtKB:Q5VVQ6	39..45		1/5 (20%)
		OTU	42..>121	CDD:303090	32/78 (41%)
		Variable-loop. /evidence=ECO:0000250\|UniProtKB:Q5VVQ6	94..104		1/9 (11%)
		His-loop. /evidence=ECO:0000250\|UniProtKB:Q5VVQ6	143..148		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..239		12/73 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..431		22/103 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..568
		T4BSS_DotH_IcmK	558..>644	CDD:289093
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1107
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835253
Domainoid	1	1.000	66	1.000	Domainoid score	I9886
eggNOG	1	0.900	-	-		E1_KOG2605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8894
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12419
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2026
SonicParanoid	1	1.000	-	-		X1801
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870