DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3251 and alg13

DIOPT Version :9

Sequence 1:	NP_608851.1	Gene:	CG3251 / 33671	FlyBaseID:	FBgn0031622	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_005161471.1	Gene:	alg13 / 557181	ZFINID:	ZDB-GENE-060307-1	Length:	889	Species:	Danio rerio

Alignment Length:	522	Identity:	146/522 - (27%)
Similarity:	218/522 - (41%)	Gaps:	108/522 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IDRFLERRQLFRKHMLGDASSLFRVVAEQVYDTQMLHYEVRMECVRYMFTKWKTFRRFVSGDFDE 84
            :|.:|....|:||.|..|||.|||.|:||:|.:|..|..:|.|||.::......|..||.|.|::
Zfish    12 MDEYLASIGLYRKMMARDASCLFRAVSEQLYYSQNYHQRIRKECVNFIRANRCNFEPFVEGSFEK 76

  Fly    85 YLWHLGKTK-TAGTILELGAMCHLYRRNVIIYE-PFDMGRMVTYNKDYKEILRIFMNSMGHFETV 147
            ||..|...| |.|.:: :.|:..||||..:||. |......:....:..:||....|: ||::.|
Zfish    77 YLERLEDPKETVGQVI-IKALSLLYRRCFVIYRYPGKPPTEIAEEDNLPKILLCCSNN-GHYDIV 139

  Fly   148 LTMQDVDMAAVCQSVSFKMLYKHLFRLPD--VDLAVEWMLYPDTFKMGTEYEFDSRGRAIR---L 207
            ........|||||::.:::||..:..:.|  :..|:|      .||.|        ||..|   .
Zfish   140 YPKSYPVDAAVCQALLYELLYTRVLGVEDNEIQAALE------GFKGG--------GRRYRNSHS 190

  Fly   208 LCRNGRSFKLDRPESTICLLENSQM--------CPFHNR-RLAMGGQFADFSCMRILLEENNIPF 263
            :|....|:  |.||      :.||.        |.|.:| |:....|       ::......:..
Zfish   191 MCSEDASY--DTPE------DRSQREDWESRGHCRFDDRPRVGAEDQ-------KVTEGSGKLAL 240

  Fly   264 SYLVAKSMDPCRYRNVELTSAIEARREAY--EFGIYIGDYNFKVGAKCQVQLDTNRRDLLSACYI 326
            .|.|.|:::|..|||||.....::|:|..  ::.::.|...| :|.||||:||...:  ....:|
Zfish   241 PYKVLKALEPELYRNVEFDVWQDSRKELQKTDYMVFAGRQYF-LGDKCQVRLDPKGK--YYNAFI 302

  Fly   327 QSIDKKKSVCKVFIEEQGKLVDVPSDNLHPLPPDEFKAWDFARKRPQRLHNSQMGRQSVQGDQQG 391
            |.:....:...|||||.|:...|...||.|:.|  ..||:..   |.|..||....:...|:..
Zfish   303 QEVGTHSTAVTVFIEELGEKHLVSLTNLKPVNP--VPAWNIT---PSRKGNSYSHAEQYPGELD- 361

  Fly   392 FVPD------------------------PMPGTAPSMPPPP--VADPRPVNVTAQQPPVFGPSRW 430
              |:                        |.||..|.:.|.|  :...|...|.:..||  .|...
Zfish   362 --PELRGRRRFFKKPRGKEMLMAVSFSRPQPGLPPRLQPGPGNIHPVRSPGVHSPAPP--PPGLI 422

  Fly   431 MEPTRPLMPNPLMIHQTGSFVFVQQPR-VGPPSVMMHVLIIVHNAPYMLAFDHAPHP-PAPQCTA 493
            .|..|| .|.|            :||| .||||....:     |..:::..|.|.:| |:.:|..
Zfish   423 YEHYRP-HPPP------------RQPRGYGPPSSARFL-----NRHHLIGPDMAYYPSPSKRCYQ 469

  Fly   494 PF 495
            .|
Zfish   470 SF 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3251	NP_608851.1	OTU	36..>115	CDD:303090	32/79 (41%)
alg13	XP_005161471.1	OTU	29..>108	CDD:303090	33/79 (42%)
alg13	XP_005161471.1	TUDOR	284..332	CDD:119391	18/49 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10322
eggNOG	1	0.900	-	-		E1_KOG2605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007272
OrthoInspector	1	1.000	-	-		mtm6497
orthoMCL	1	0.900	-	-		OOG6_114775
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2026
SonicParanoid	1	1.000	-	-		X1801
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.740