DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3251 and OTUD1

DIOPT Version :9

Sequence 1:	NP_608851.1	Gene:	CG3251 / 33671	FlyBaseID:	FBgn0031622	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001138845.1	Gene:	OTUD1 / 220213	HGNCID:	27346	Length:	481	Species:	Homo sapiens

Alignment Length:	175	Identity:	40/175 - (22%)
Similarity:	70/175 - (40%)	Gaps:	32/175 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EVRKARDPIDRFLERRQLFRKHMLGDASSLFRVVAEQVYDTQMLHYEVRMECVRYMFTKWKTFRR 76
            ||.|.    |::|.:|..:|.|::.|.:.|:|.|::.||..|.||.|:|.:.|.|:......|..
Human   296 EVEKQ----DKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSP 356

  Fly    77 FVSGDFDEYLWHLGKTKTAGTILELGAMCHLYRRNVII-----YEPFDMGRMVTY---NKDYKEI 133
            .:.||..|::....:........||.||..:...|:.:     .|...:..|:.|   ....:..
Human   357 LIEGDVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPS 421

  Fly   134 LRIFMNSMGHFETVLTMQDVDMAAVCQSVSFKMLYKHLFRLPDVD 178
            :.:...|.||::.|                    :.|.:..|:.|
Human   422 IWLSWLSNGHYDAV--------------------FDHSYPNPEYD 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3251	NP_608851.1	OTU	36..>115	CDD:303090	22/83 (27%)
OTUD1	NP_001138845.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..282
		Cys-loop	314..320		1/5 (20%)
		OTU	315..432	CDD:280496	27/116 (23%)
		His-loop	369..379		0/9 (0%)
		Variable-loop	426..431		1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145157
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2605
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4984
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.650