DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3355 and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_608848.1	Gene:	CG3355 / 33667	FlyBaseID:	FBgn0031619	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	273	Identity:	105/273 - (38%)
Similarity:	145/273 - (53%)	Gaps:	32/273 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RNQCTAKQ----NCF-CGT-PNVNRIVGGQQVRSNKYPWTAQLVKG-RHYPRLFCGGSLINDRYV 114
            ||.||:.|    .|. ||. |..:||||||.|...::||.|.:..| ||    .||||::..|:|
Human   193 RNNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGFRH----TCGGSVLAPRWV 253

  Fly   115 LTAAHCVHGNRDQITIRLLQIDRSSRDPGIVRK----------VVQTTVHPNYDPNRIVNDVALL 169
            :|||||:|      :.||.::.......|:|..          |.:...||.|.......|||||
Human   254 VTAAHCMH------SFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALL 312

  Fly   170 KLESPVPLTGNMRPVCLPEANHNF-DGKTAVVAGWGLIKEGGV-TSNYLQEVNVPVITNAQCRQT 232
            :|::.:..:..:..||||....:| .|....|:|||....... :|:.||:..||:.:...|..:
Human   313 RLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSS 377

  Fly   233 -RYKDKIAEVMLCAGLVQQGGKDACQGDSGGPLIVNEG-RYKLAGVVSFGYGCAQKNAPGVYARV 295
             .|...:...|||||.: .|..|||||||||||:..:| .::|.||||:|.|||:.|.|||||:|
Human   378 CVYSGALTPRMLCAGYL-DGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKV 441

  Fly   296 SKFLDWIRKNTAD 308
            ::|||||.....|
Human   442 AEFLDWIHDTAQD 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3355	NP_608848.1	Tryp_SPc	75..302	CDD:214473	93/241 (39%)
CG3355	NP_608848.1	Tryp_SPc	76..305	CDD:238113	94/243 (39%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133	8/19 (42%)
		Tryp_SPc	217..448	CDD:214473	93/241 (39%)
		Tryp_SPc	218..451	CDD:238113	94/243 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4057
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960