DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3355 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_608848.1	Gene:	CG3355 / 33667	FlyBaseID:	FBgn0031619	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	255	Identity:	109/255 - (42%)
Similarity:	162/255 - (63%)	Gaps:	22/255 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KQNCFCGT--PNVNRIVGGQQVRSNKYPWTAQL-VKGRHYPRLFCGGSLINDRYVLTAAHCVHGN 124
            :::|.||.  |: :|||||......::||.|.| ::|||    .|||:||.||:|:|||||.  .
  Rat   563 EEHCDCGLQGPS-SRIVGGAMSSEGEWPWQASLQIRGRH----ICGGALIADRWVITAAHCF--Q 620

  Fly   125 RDQI------TIRLLQIDRSSRDPGIVR-KVVQTTVHPNYDPNRIVNDVALLKLESPVPLTGNMR 182
            .|.:      |:.|.::.::||.||.|. ||.:..:||.::.:....|||||:|:.||..:..:|
  Rat   621 EDSMASPRLWTVFLGKMRQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVR 685

  Fly   183 PVCLPEANHNFD-GKTAVVAGWGLIKEGGVTSNYLQEVNVPVITNAQCRQTRYKDKIAEVMLCAG 246
            |||||..:|.|: |:...:.|||..:|||..|:.||:|:|.:|....|.:. |:.::...|||||
  Rat   686 PVCLPARSHFFEPGQHCWITGWGAQREGGPGSSTLQKVDVQLIPQDLCNEA-YRYQVTPRMLCAG 749

  Fly   247 LVQQGGKDACQGDSGGPLIVNE--GRYKLAGVVSFGYGCAQKNAPGVYARVSKFLDWIRK 304
             .::|.||||||||||||:..|  ||:.|||:||:|.||.:.|..|||.||::.::||::
  Rat   750 -YRKGKKDACQGDSGGPLVCKEPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVVNWIQQ 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3355	NP_608848.1	Tryp_SPc	75..302	CDD:214473	103/237 (43%)
CG3355	NP_608848.1	Tryp_SPc	76..305	CDD:238113	104/240 (43%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486	0/2 (0%)
		Tryp_SPc	576..806	CDD:214473	103/237 (43%)
		Tryp_SPc	577..809	CDD:238113	104/240 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BJ04
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710