DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3355 and HGF

DIOPT Version :9

Sequence 1:	NP_608848.1	Gene:	CG3355 / 33667	FlyBaseID:	FBgn0031619	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	NP_000592.3	Gene:	HGF / 3082	HGNCID:	4893	Length:	728	Species:	Homo sapiens

Alignment Length:	260	Identity:	77/260 - (29%)
Similarity:	117/260 - (45%)	Gaps:	51/260 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 CGTPNVNRIVGGQQVRSNKYPWTAQLVKGRHYPRLFCGGSLINDRYVLTAAHC------------ 120
            |......|:|.|...|:| ..|...|   |:..:..||||||.:.:||||..|
Human   487 CAKTKQLRVVNGIPTRTN-IGWMVSL---RYRNKHICGGSLIKESWVLTARQCFPSRDLKDYEAW 547

  Fly   121 -----VHGNRDQITIRLLQIDRSSRDPGIVRKVVQTTVHPNYDPNRIVNDVALLKLESPVPLTGN 180
                 |||..|:...::|.:.:      :|           |.|..  :|:.|:||..|..|...
Human   548 LGIHDVHGRGDEKCKQVLNVSQ------LV-----------YGPEG--SDLVLMKLARPAVLDDF 593

  Fly   181 MRPVCLPEANHNFDGKTAV-VAGW---GLIKEGGVTSNYLQEVNVPVITNAQCRQ-TRYKDKIAE 240
            :..:.||........||:. |.||   |||...|:    |:..::.::.|.:|.| .|.|..:.|
Human   594 VSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGL----LRVAHLYIMGNEKCSQHHRGKVTLNE 654

  Fly   241 VMLCAGLVQQGGKDACQGDSGGPLIVNEGRYKLA-GVVSFGYGCAQKNAPGVYARVSKFLDWIRK 304
            ..:||| .::.|...|:||.||||:..:.:.::. ||:..|.|||..|.||::.||:.:..||.|
Human   655 SEICAG-AEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHK 718

Fly 305 304
Human 719 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3355	NP_608848.1	Tryp_SPc	75..302	CDD:214473	73/249 (29%)
CG3355	NP_608848.1	Tryp_SPc	76..305	CDD:238113	75/252 (30%)
HGF	NP_000592.3	PAN_APPLE	39..122	CDD:238074
		KR	126..208	CDD:214527
		KR	210..290	CDD:214527
		KR	304..384	CDD:214527
		KR	388..470	CDD:238056
		Tryp_SPc	494..716	CDD:214473	73/249 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000