DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and SLC6A5

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_004202.4	Gene:	SLC6A5 / 9152	HGNCID:	11051	Length:	797	Species:	Homo sapiens

Alignment Length:	865	Identity:	284/865 - (32%)
Similarity:	434/865 - (50%)	Gaps:	151/865 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 ANQPTAAVSTSTVTFTIDDCNEEGDAIP--------AAASVPAPVTMPAISPTPA-------TLT 178
            ||.|.||.:..         :.:|...|        .||:.|.|..:|..:.|.|       ...
Human    14 ANSPEAAAAQG---------HPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQTFQSADARA 69

  Fly   179 CTTTTTMAGDSVAVSPLSMELKSRLGSHHSSMRSVVSGYLPGLSDSSGNLVGGVSMATSGLQAPN 243
            |.......|.....||       |..:..:::|.:                    ....|.||..
Human    70 CEAERPGVGSCKLSSP-------RAQAASAALRDL--------------------REAQGAQASP 107

  Fly   244 PLYMQPQASLSGSSYHFHELAGNQIYSDVTSVRSL---ASIGIGSTDGRKLVIRRVPTTANELFD 305
            |         .|||.     .||.::..:..:|..   |::.:|     |..:.|..|......:
Human   108 P---------PGSSG-----PGNALHCKIPFLRGPEGDANVSVG-----KGTLERNNTPVVGWVN 153

  Fly   306 MVNPQTPPPLGVDDDDSYLDMS--------DETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWR 362
            |  .|:...|..|...|.|..|        ||.......:.:|::|:.|:|:.:||:||||||||
Human   154 M--SQSTVVLATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWR 216

  Fly   363 FPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVS 427
            |||:.:::|||.||:||.::|.:..:|:.|:|:|:||:..:||: ::.:..|..:|.|:|.:::|
Human   217 FPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPV-SVWKAIPALQGCGIAMLIIS 280

  Fly   428 FLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDC------------------------- 467
            .|::.||:|||.|:::|.|.||.:.:||..|||.||||:|
Human   281 VLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNST 345

  Fly   468 ----WVPQRKGIN--ASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFA 526
                ..|....:|  :.|..|..:.|||:|:..||:||.|:||||.:||.|..||..||::||.:
Human   346 FCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYAS 410

  Fly   527 TWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNF 591
            ..|.||:|.||.|||||||:|:::||::|.|||.||..|:.:|..|||.:|.:|.||.:||:|.|
Human   411 LAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIF 475

  Fly   592 NSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIG 656
            .||...:|.:|:.:||||::||..|||:.|:..|..||:..|...||.:|.:|.|:..|:.:|..
Human   476 FSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD 540

  Fly   657 DGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYH 721
            .|||:.|||||:|:.::|.:..||::||.|||.|||::.||.:|.:||||.|.||::::.|   .
Human   541 QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTH---K 602

  Fly   722 EIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQ 786
            .:..|..|:...:.|.|.|.|||||.|||:|.||||..::.:|..:::.|::.||..|..::::.
Human   603 PVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEM 667

  Fly   787 MTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIP 851
            |.|..|:.:.:.||..:.|.:|..|...|...:...||  |.|.||:|:..:||:..:.|:|.||
Human   668 MIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTY--GSYRYPNWSMVLGWLMLACSVIWIP 730

  Fly   852 GYAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHHCEHDYPEQEQFMLAQEMATVYKPTNPHL 916
            ...||....:.| .|.||::....|.                |:...| |||.....||.....|
Human   731 IMFVIKMHLAPG-RFIERLKLVCSPQ----------------PDWGPF-LAQHRGERYKNMIDPL 777

  Fly   917 -------------LNLGQKC 923
                         |.||.:|
Human   778 GTSSLGLKLPVKDLELGTQC 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	227/569 (40%)
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..118		29/153 (19%)
SLC6A5	NP_004202.4	SLC6sbd_GlyT2	191..787	CDD:271389	236/619 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820