Protein Alignment ine and Slc6a2

DIOPT Version :10

• Sequence 1: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_112633.2
• Gene: Slc6a2 / 83511
• RGDID: 621822
• Length: 617
• Species: Rattus norvegicus
• Alignment Length: 641
• Identity: 243/641 - (37%)
• Similarity: 359/641 - (56%)
• Gaps: 63/641 - (9%)

  Fly   303 LFDMVNPQTPPPLGVDDD-----------------------DSYLDMSDETAQLKPRQQHWANKM 344
            |...:.||..|.||..|.                       ...|...|..||  ||:. |..|:
  Rat     2 LLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKEHNGVQCLLASQDGDAQ--PRET-WGKKI 63

  Fly   345 QFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGAL 409
            .|:|:.:|::|.|.|||||||:|||:|||.||:||.:.|.|..:||.:|||::||:...| ...:
  Rat    64 DFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREG-AATV 127

  Fly   410 GQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKG 474
            .::||.|||.|.|.::::..:..||:|||.:|:||.|.||...:||.:|.:.||:|:|..|  |.
  Rat   128 WKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDP--KL 190

  Fly   475 INASA-PDTSR------TPSEEFFENKVLQI--SGGLEYPGMMRWELFACLICAWLMVYFATWKS 530
            :|||. .|.::      ||:.||:|..||.:  |.|:...|:.:|:|..||:...:::||:.||.
  Rat   191 LNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKG 255

  Fly   531 IKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLG 595
            :|:|.||.:.|||.|:.::.:|:|..|||.||:.|:..:....:..||.|.|||:||:|.|.|||
  Rat   256 VKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLG 320

  Fly   596 ITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPG 660
            ..||.:|:||||||::||..||.:..|.:|.:||.:.|...||.||.:|.|....:.||..:|.|
  Rat   321 AGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAG 385

  Fly   661 MIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVV 725
            ::||:||:|::.:..:..|||:||.|||.|||:|....:|.|:|.:.|.| :.:|||.      .
  Rat   386 LVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDF-QVLKRHR------K 443

  Fly   726 LFVCVISC---LFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQM 787
            ||.|.::.   |..|..|.:||||...|:|.:||..:|:|....:.|.::||||..|.|.:::||
  Rat   444 LFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQM 508

  Fly   788 TGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPG 852
            .|..|..|.|.||..:.|..|..:.|:|:||:...||.:  |.||.||..:||..|..|:|.:|.
  Rat   509 MGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDD--YVYPPWANWVGWGIALSSMILVPA 571

  Fly   853 YAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHH--CEHDYPEQEQFMLAQEMA 906
            |.:..|....| :.|||:...:.|.       .|||  .:.|.   .||.|...:|
  Rat   572 YVIYKFFSIRG-SLWERVAYGITPE-------NEHHLVAQRDV---RQFQLRHWLA 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	221/550 (40%)
Slc6a2	NP_112633.2	SLC5-6-like_sbd	56..615	CDD:444915	230/582 (40%)