Protein Alignment ine and slc6a3

DIOPT Version :9

• Sequence 1: NP_001162871.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_571830.1
• Gene: slc6a3 / 80787
• ZFINID: ZDB-GENE-010316-1
• Length: 629
• Species: Danio rerio
• Alignment Length: 746
• Identity: 254/746 - (34%)
• Similarity: 392/746 - (52%)
• Gaps: 134/746 - (17%)

  Fly   167 MPAISPTPA-----TLTCTTTTTMAGDSVAVSPLSMELKSRLGSHHSSMRSVVSGYLPGLSDSSG 226
            ||.:...||     |.|.|..::::|.|.|..|..:||.
Zfish     1 MPMLRGRPAVTHTRTRTHTHMSSVSGSSSAAGPREVELV-------------------------- 39

  Fly   227 NLV---GGVSMATSGLQAPNPLYMQPQASLSGSSYHFHELAGNQIYSDVTSVRSLASIGIGSTDG 288
             ||   .||...:|.|:.|            |:..|.|
Zfish    40 -LVKEQNGVQFTSSSLRNP------------GAHSHTH--------------------------- 64

  Fly   289 RKLVIRRVPTTANELFDMVNPQTPPPLGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGY 353
                              .:..|.|                :.|   :::.|..|:.|:|:.||:
Zfish    65 ------------------THTHTHP----------------SGQ---QRETWGKKIDFLLSVIGF 92

  Fly   354 SVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKG 418
            :|.|.|||||||:|||:|||.|||||.:.:.|..:||.:|||::|||...|..| :.::||:|||
Zfish    93 AVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQYNREGAAG-VWKICPIFKG 156

  Fly   419 AGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINASAPDTS 483
            .|...:::|..:.:||:|||.::::|.|:||..|:|||.|||.||:|:|..|....:|    ||.
Zfish   157 VGFTVILISLYVGSYYNVIIAWALFYLFSSFSGELPWIHCNNTWNSPNCSDPNATLLN----DTY 217

  Fly   484 R-TPSEEFFENKVLQI--SGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFP 545
            : ||:.|:||..||.:  |.|::..|..||:|.|||....:::||:.||.:|:|.||.:.|||.|
Zfish   218 KTTPALEYFERGVLHVHESSGIDDLGAPRWQLTACLAVVIVVLYFSLWKGVKTSGKVVWITATMP 282

  Fly   546 FVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKY 610
            :|::.:|::|.|||.||.:|::.:....:..|.:|.|||.||:|...|||:.||.:|:|:||||:
Zfish   283 YVVLTVLLLRGVTLPGAIDGIKAYLSVDFLRLYDAQVWIEAATQICFSLGVGFGVLIAFSSYNKF 347

  Fly   611 NNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPY 675
            :||..||.:..|::|.:||...|...||.||.::.:.|..:..|..||||::|::||:|:|.:|.
Zfish   348 SNNCYRDAIITSSINSLTSFFSGFVIFSFLGYMSQKHNVALDKVATDGPGLVFIIYPEAIATLPG 412

  Fly   676 AQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNI 740
            :.:|||:||.|||.||::|....:|.|:|.:.|.| :::.:|   .|:..||:.|.:.|..:..:
Zfish   413 SSVWAVIFFIMLLTLGIDSAMGGMESVITGLIDEF-KFLHKH---RELFTLFIVVSTFLISLICV 473

  Fly   741 IQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGP 805
            ..||||.|.|:||:||..:|:|....:.|.||||||..|.|.::::|.|:.|..|.|.||..:.|
Zfish   474 TNGGIYVFTLLDHFAAGTSILFGVLIEAIGIAWFYGVDRFSDDIEEMIGQRPGLYWRLCWKFVSP 538

  Fly   806 CLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERI 870
            |.|..:.|:|...::.|.|  |.|.:|.||..:||..:..|:|.:|.||...|....| :|.:::
Zfish   539 CFLLFMVVVSFATFNPPKY--GSYYFPTWATMVGWCLSISSMIMVPLYAFYKFCSLPG-SFCDKL 600

  Fly   871 RNTLRPNIYECKICGEHHCEHDYPEQEQFML 901
            ...:.|..       :||.. :..|..||.|
Zfish   601 AYAITPET-------DHHLV-ERGEVRQFTL 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	221/541 (41%)
slc6a3	NP_571830.1	SLC6sbd_DAT1	76..623	CDD:212083	227/566 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820