DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ine and slc6a4a

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_001035061.1	Gene:	slc6a4a / 664719	ZFINID:	ZDB-GENE-060314-1	Length:	646	Species:	Danio rerio

Alignment Length:	612	Identity:	226/612 - (36%)
Similarity:	361/612 - (58%)	Gaps:	27/612 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 STDGRKLVIRRVPT----------TANELFDMVNPQTPPP---LGVD---DDDSYLDMSDETAQL 333
            |.:..:||:..||.          ..:..:...:||:|..   .|.|   ...::..:..:...|
Zfish    23 SQENGRLVVDSVPEKDQKSGSGPGQVSNGYRSTSPQSPKEGAGTGTDRVNTPGTFRTLVVQQTSL 87

  Fly   334 KPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVG 398
            .|.::.|:.||.|:|:.|||:|.|||||||||:||::|||.||:||.::.....:||.:|||::|
Zfish    88 DPPRETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYLLMAVFGGVPLFYMELALG 152

  Fly   399 QYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWN 463
            |:...|.|.....:||:|||.|.|..:::..::.||:.|:.:::||..:||:..:||..||||||
Zfish   153 QFHRSGCISIWKHVCPIFKGIGFAICIIALYIAFYYNTIMAWALYYLLSSFRATLPWTTCNNRWN 217

  Fly   464 TPDCWVPQRKGINASAPDTSRTPSEEFFENKVLQI--SGGLEYPGMMRWELFACLICAWLMVYFA 526
            ||:|.......:|.|..:.|.:|:|||:..:|||:  |.||...|.:.|:|..||:..:.:|||:
Zfish   218 TPNCTHYLSTDLNVSWTNNSISPAEEFYVRQVLQVHLSPGLHQLGWVSWQLALCLLFIFTVVYFS 282

  Fly   527 TWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNF 591
            .||.:|:|.||.:.|||||:::::||::|..||.||..|:.|:.:|.|.:|....||::||:|.|
Zfish   283 IWKGVKTSGKVVWVTATFPYLVLLILLIRGATLPGAWRGVVFYLKPDWKKLLTTTVWLDAAAQIF 347

  Fly   592 NSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIG 656
            .|||..||.:::|||||.::||..:|.:..|:||.:||.|.|...|:.||.:|..:...|..|..
Zfish   348 FSLGPGFGVLLAFASYNPFHNNCYKDALITSSVNCLTSFLSGFVIFTVLGYMAEMRQQGVETVAK 412

  Fly   657 D-GPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGY 720
            | ||.::|::|.:|:|.||.|..:|::||.|::.|||:|.||.:|.|:|::.|.||..:.|...:
Zfish   413 DAGPSLLFIIYAEAIANMPAATFFAIIFFLMIIMLGLDSTFAGLEGVITAMLDEFPHLLARRREW 477

  Fly   721 HEIVVLFVCVISCLFG-MPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNV 784
              .|:..|||  |..| :..:..||.:..:|.:.||....::.:.|.::||::|||||.|...:|
Zfish   478 --FVLGLVCV--CYLGALSTLTYGGAFVVKLFEEYATGPAVITVVFLEVIAVSWFYGTTRFCNDV 538

  Fly   785 KQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLIC 849
            :.|.|.||..:.|.||:.:.||.|..| ::|.:.: .|......|.||.|...:|:.....|.||
Zfish   539 QLMLGFAPGLFWRVCWIAICPCFLLFI-IVSFLAF-PPEVKLFDYLYPFWTTVLGYCIGVSSFIC 601

  Fly   850 IPGYAVINFLRSSGDTFWERIRNTLRP 876
            :|.|.|.:.:.:.| ||.:|:...:.|
Zfish   602 VPSYMVYHLVTTKG-TFQQRLLKGITP 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	213/542 (39%)
slc6a4a	NP_001035061.1	SLC5-6-like_sbd	91..628	CDD:294310	214/544 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820