Protein Alignment ine and SLC6A12

DIOPT Version :9

• Sequence 1: NP_001162871.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_001116319.1
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 240/570 - (42%)
• Similarity: 364/570 - (63%)
• Gaps: 9/570 - (1%)

  Fly   312 PPPLG-VDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVF 375
            ||.:. |.::...||..||. |:|.|.| |.|||:|||:..|..:||||||||||:|||:|||.|
Human    12 PPAVSWVPEEGEKLDQEDED-QVKDRGQ-WTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAF 74

  Fly   376 LVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGY 440
            .:||.|..|:|.||:.|:|:::||||.:|.:.|..::||||:|.||||||:...::.||.:|:.:
Human    75 FIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAW 139

  Fly   441 SIYYFFTSFKTEMPWIDCNNRWNTPDCW-VPQRKGINASAP-DTSRTPSEEFFENKVLQISGGLE 503
            :::|.|:||.:|:||..|||.|||..|. .....|.....| :...:|..||:|.:||.|:.|:.
Human   140 ALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIH 204

  Fly   504 YPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRF 568
            ..|.:||||..||:.||::.||..||.:||:.||.|||||||:::::||::|.|||.||.:|:.:
Human   205 DLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIY 269

  Fly   569 FFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVG 633
            :.:|....||:..||::|.:|.|.|..|..|.:.:..|||||:||..:|.:|:..:|..||.:.|
Human   270 YLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAG 334

  Fly   634 IFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAI 698
            ...||.||.::.||...:.:|...|||:.|:.:|:|:..||.:|||:.:||.||:.|||:|||..
Human   335 FVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVC 399

  Fly   699 VEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS-VTIMF 762
            ||.:||:..|.|||.:::. |..|:::|.:.|:..|.|:..:.:||:|.|||.|:||:| :.::|
Human   400 VECLVTASIDMFPRQLRKS-GRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLF 463

  Fly   763 LAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNG 827
            |:..:::.|:|.||..|...|::.|.|..|...::..||.|.|.|..|.::.||..| .|..:|.
Human   464 LSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKY-TPLKYNN 527

  Fly   828 RYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPN 877
            .|.||.|.|.|||..|..|::|:|.:.||..|::.| .|.:|:|..:.|:
Human   528 VYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRG-PFRKRLRQLITPD 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	229/541 (42%)
SLC6A12	NP_001116319.1	SLC6sbd_BGT1	35..575	CDD:212080	230/543 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820