DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and SLC6A11

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_055044.1	Gene:	SLC6A11 / 6538	HGNCID:	11044	Length:	632	Species:	Homo sapiens

Alignment Length:	546	Identity:	229/546 - (41%)
Similarity:	345/546 - (63%)	Gaps:	13/546 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 HWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGR 403
            ||.||::|||:..|..:||||||||||:|||:|||.||:||.:....|.||:.|:|.::||:|..
Human    52 HWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSE 116

  Fly   404 GPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCW 468
            |.|....::||||:|.|.|:.|:...::.||.:|:.::|:|....|.||:||..|.:.|||.:|.
Human   117 GGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCV 181

  Fly   469 VPQRKGINAS-----APDTSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATW 528
            ..|:  :|.|     :...:.:|..||:|::||.||.|:|:.|.:||||..||:.||.:.||..|
Human   182 EFQK--LNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIW 244

  Fly   529 KSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNS 593
            |..||:.||.|.|||||:::::||::|.|||.||:||::|:..|..|.|.:..||::|.:|.|.|
Human   245 KGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFS 309

  Fly   594 LGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDG 658
            ..|..|.:.:..|||.||||..||.:.:..:|..||.:.|...||.||.:|.||...:.:|...|
Human   310 YAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESG 374

  Fly   659 PGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGY-HE 722
            ||:.|:.||:|:..||.:.|||.:||.||:.|||:|||..||.:||::.|.:|:..:|  || .|
Human   375 PGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRR--GYRRE 437

  Fly   723 IVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAWFYGTGRLSKNVKQ 786
            :::|.:.|||...|:..:.:||:|.|||.|.|||| :.::|:|..:.|.|.|.||:.|...|::.
Human   438 LLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIED 502

  Fly   787 MTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIP 851
            |.|..|...::.||:::.|.:...|::..||.| :|..:|..||||.|.|||||:.|..|::|||
Human   503 MIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKY-KPLKYNNIYTYPAWGYGIGWLMALSSMLCIP 566

  Fly   852 GYAVINFLRSSGDTFWERIRNTLRPN 877
            .:..|...::.| |..|:::....|:
Human   567 LWICITVWKTEG-TLPEKLQKLTTPS 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	228/543 (42%)
SLC6A11	NP_055044.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
SLC6A11	NP_055044.1	SLC6sbd_GAT3	49..590	CDD:212077	228/543 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820