Protein Alignment ine and SLC6A8

DIOPT Version :9

• Sequence 1: NP_001162871.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_005620.1
• Gene: SLC6A8 / 6535
• HGNCID: 11055
• Length: 635
• Species: Homo sapiens
• Alignment Length: 658
• Identity: 245/658 - (37%)
• Similarity: 367/658 - (55%)
• Gaps: 87/658 - (13%)

  Fly   264 AGNQIYS---------------DVTSVRSLASIGIGSTDGRKLVIRRVPTTANELFDMVNPQTPP 313
            |.|.|||               |....:....:|:|:..||..|
Human     6 AENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAV--------------------- 49

  Fly   314 PLGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVP 378
                                 |.::.|..:|.|:::|:|::|||||||||||:|||:||||||:|
Human    50 ---------------------PPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIP 93

  Fly   379 YCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIY 443
            |.:|..:..||:.|:|:|:||:...|.|. :..:||||||.|.||:|:.|..:|||.:::.:..|
Human    94 YVLIALVGGIPIFFLEISLGQFMKAGSIN-VWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFY 157

  Fly   444 YFFTSFKTEMPWIDCNNRWNTPDCWVPQRKG--INASAPDTS-------RTPSEEFFENKVLQIS 499
            |...||.|.:||..|.:.||||||....|..  .|||..:.:       |:|..||:|||||::|
Human   158 YLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLS 222

  Fly   500 GGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAE 564
            ||||.||.:.||:..||:..|::|||..||.:||:.|:.|||||||:|::::|:||.|.|.||.:
Human   223 GGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALD 287

  Fly   565 GLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITS 629
            |:.::.:|.||:|.:..|||:|.:|.|.|..|..|::.:..|||::|||..:|.:.::.:|..||
Human   288 GIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTS 352

  Fly   630 LLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNS 694
            ...|...||.||.:|.||..::..|...|||:.|:.||:|:..||.|.|||.:||||||.|||:|
Human   353 FFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDS 417

  Fly   695 QFAIVEVVVTSIQDGFPRWIKRHLGYH-----EIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHY 754
            ||..||..:|.:.|..|      ..|:     ||.|...|.:..:..:..:..||:|.|||.|:|
Human   418 QFVGVEGFITGLLDLLP------ASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 476

  Fly   755 AAS-VTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLIN 818
            :|| .|:::.||.:.:.:||.||..|...::..|.|..|..:::.||....|.:...|::.:::
Human   477 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV- 540

  Fly   819 YHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKI 883
            |:||..:|..|.||.|...:||.||..|::|:|.:.:...||:.| |..||.::..:|      |
Human   541 YYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKG-TMAERWQHLTQP------I 598

  Fly   884 CGEHHCEH 891
            .|.||.|:
Human   599 WGLHHLEY 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	227/553 (41%)
SLC6A8	NP_005620.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		5/21 (24%)
		SLC6sbd_CT1	52..621	CDD:271397	233/570 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820