Protein Alignment ine and SLC6A7

DIOPT Version :9

• Sequence 1: NP_001162871.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: XP_016865256.1
• Gene: SLC6A7 / 6534
• HGNCID: 11054
• Length: 754
• Species: Homo sapiens
• Alignment Length: 662
• Identity: 250/662 - (37%)
• Similarity: 365/662 - (55%)
• Gaps: 74/662 - (11%)

  Fly   309 PQTPPPLGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGG 373
            |.||..|....|...:|:..:.|   ..:.:|..|:.|:|:||||.|||||||||||..|.:|||
Human    93 PVTPDLLMTPSDQGDVDLDVDFA---AHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGG 154

  Fly   374 VFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVII 438
            .|||||.::|.||.|||.|:|||:||::..||: |:.::.|||||||.|.:::..|::.||::||
Human   155 AFLVPYFLMLAICGIPLFFLELSLGQFSSLGPL-AVWKISPLFKGAGAAMLLIVGLVAIYYNMII 218

  Fly   439 GYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQR--KGINASAP---DTSRTPSEEFFENK---- 494
            .|.::|.|.|..:::||..|.|.|||..| :..|  |..|.:.|   ..:.:||||::...
Human   219 AYVLFYLFASLTSDLPWEHCGNWWNTELC-LEHRVSKDGNGALPLNLTCTVSPSEEYWSQTHTEA 282

  Fly   495 ---------------------------------VLQISG--GLEYPGMMRWELFACLICAWLMVY 524
                                             ||.|.|  |:..||.:||.|..||:.||::|:
Human   283 EEEGRRGRVVSNSYPQVIFLPQPPKAEEGVSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVF 347

  Fly   525 FATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQ 589
            ....|.:|||.||.|||||||::::::|:||.|||.||.:|::|:..|::..|.::.|||.||.|
Human   348 LCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQ 412

  Fly   590 NFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDV 654
            .|.|||:.||.:::|||||.::.||.|||..|:..|.|||:|.|...||.||.::.|....|..|
Human   413 IFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQV 477

  Fly   655 IGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLG 719
            ...|||:.||||||||..:|.:..|:.:||||||.|||:||||.:|.:||::.|.||.:::..
Human   478 AKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPK-- 540

  Fly   720 YHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNV 784
             ..:....:||...|.|:.....||:|:..|:|.|:||..:|.:.....:|:...||..|..:::
Human   541 -KAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDI 604

  Fly   785 KQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLIC 849
            ..|.|..|..|.|:|||.|.|..|.|:.|.|::.|....|  |.|.:|.||..:|.:....|.:.
Human   605 HMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEY--GSYRFPPWAELLGILMGLLSCLM 667

  Fly   850 IPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHHCEHDY-PEQEQFMLAQEMATVY---- 909
            ||...::..||..| :.|||::...||.:             |: |..|:......:||:.
Human   668 IPAGMLVAVLREEG-SLWERLQQASRPAM-------------DWGPSLEENRTGMYVATLAGSQS 718

  Fly   910 -KPTNPHLLNLG 920
             ||...|:...|
Human   719 PKPLMVHMRKYG 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	232/582 (40%)
SLC6A7	XP_016865256.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820