DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and SLC6A6

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_001127839.2	Gene:	SLC6A6 / 6533	HGNCID:	11052	Length:	721	Species:	Homo sapiens

Alignment Length:	607	Identity:	247/607 - (40%)
Similarity:	364/607 - (59%)	Gaps:	40/607 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 DETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLF 392
            ||.....|:::.|::|:.|||:..|..|||||||||||:|||:|||.||:||.|.||...:|:.|
Human   133 DEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFF 197

  Fly   393 MELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWID 457
            :|:.:||||..|.|....::||||.|.|.||||:..|::.||.||:.::.||.|.||:.|:||..
Human   198 LEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAH 262

  Fly   458 CNNRWNTPDCW---VPQRKGINASAPDTSRT-PSEEFFENKVLQISGGLEYPGMMRWELFACLIC 518
            ||:.||||.|.   :.:.|.:..:...|:.| |..||:|..||.:|.|:::||.::|:|..||:.
Human   263 CNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLL 327

  Fly   519 AWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVW 583
            .||:.:|..||.::|:.||.||||||||.::::|:||.:||.||..|::|:..|..:.|::..||
Human   328 VWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVW 392

  Fly   584 INAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQN 648
            |:|.:|.|.|..|..|:|.|..|||||..|..||.:.:..:|..||.:.|...||.||.:|.||.
Human   393 IDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQG 457

  Fly   649 TNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRW 713
            .::.||...|||:.|:.||:|:..||....|:::||.|||.|||:|||..||..:||:.|.:|.:
Human   458 VDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSF 522

  Fly   714 IKRHLGY-HEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAWFYG 776
            :::  || .||.:.|||.||.|.|:..:.:||:|.|||.|:|||| |.::::||.:...|||.||
Human   523 LRK--GYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 585

  Fly   777 TGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWM 841
            ...|...::.|.|..|..:::..|.|:.|.|....::.||:.|...|| |..|.||:||.|:||.
Human   586 GDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTY-NKTYVYPNWAIGLGWS 649

  Fly   842 FASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHHCEHDYPEQEQFMLAQEMA 906
            .|..|::|:|...||...::.| .|..|::..|.|.                 |..::.:.:|.|
Human   650 LALSSMLCVPLVIVIRLCQTEG-PFLVRVKYLLTPR-----------------EPNRWAVEREGA 696

  Fly   907 TVY-----------KPTNPHLL 917
            |.|           |||  |::
Human   697 TPYNSRTVMNGALVKPT--HII 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	234/544 (43%)
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	234/544 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820