Protein Alignment ine and SLC6A4

DIOPT Version :9

• Sequence 1: NP_001162871.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_001036.1
• Gene: SLC6A4 / 6532
• HGNCID: 11050
• Length: 630
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 228/589 - (38%)
• Similarity: 356/589 - (60%)
• Gaps: 30/589 - (5%)

  Fly   313 PPLGVDDDDSYLDMSDET---AQL-KPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGG 373
            |..|..||..:...:..|   |:| :..::.|..|:.|:|:.|||:|.|||||||||:||::|||
Human    51 PSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGG 115

  Fly   374 VFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVII 438
            .||:||.|:.....|||.:|||::|||...|.|....::||:|||.|.|..:::|.:::||:.|:
Human   116 AFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM 180

  Fly   439 GYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINASAPDT------SRTPSEEFFENKVLQ 497
            .:::||..:||..::||..|.|.|||.:|       .|..:.|.      |.:|:|||:...|||
Human   181 AWALYYLISSFTDQLPWTSCKNSWNTGNC-------TNYFSEDNITWTLHSTSPAEEFYTRHVLQ 238

  Fly   498 I--SGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLD 560
            |  |.||:..|.:.|:|..|::..:.::||:.||.:|:|.||.:.|||||::::.:|:||..||.
Human   239 IHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLP 303

  Fly   561 GAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVN 625
            ||..|:.|:.:|.|.:|....|||:||:|.|.|||..||.:::||||||:|||..:|.:..|.||
Human   304 GAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVN 368

  Fly   626 MITSLLVGIFAFSTLGNLALEQNTNVRDVIGD-GPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLC 689
            .:||.:.|...|:.||.:|..:|.:|.:|..| ||.::|:.|.:|:|.||.:..:|::||.||:.
Human   369 CMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLIT 433

  Fly   690 LGLNSQFAIVEVVVTSIQDGFPR-WIKRHLGYHEIVVLFVCVISCLFG-MPNIIQGGIYYFQLMD 752
            |||:|.||.:|.|:|::.|.||. |.||    .|..||.| ||:|.|| :..:..||.|..:|::
Human   434 LGLDSTFAGLEGVITAVLDEFPHVWAKR----RERFVLAV-VITCFFGSLVTLTFGGAYVVKLLE 493

  Fly   753 HYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLI 817
            .||....::.:|..:.:|::||||..:..::||:|.|.:|.::.|.||:.:.|  ||.::::...
Human   494 EYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISP--LFLLFIICSF 556

  Fly   818 NYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECK 882
            ....|.....:|.||.|:..:|:...:.|.||||.|.....:.:.| ||.|||..::.|......
Human   557 LMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPG-TFKERIIKSITPETPTEI 620

  Fly   883 ICGE 886
            .||:
Human   621 PCGD 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	218/549 (40%)
SLC6A4	NP_001036.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59		3/7 (43%)
		5HT_transport_N	24..64	CDD:397524	4/12 (33%)
		SLC6sbd_SERT	79..615	CDD:271399	218/550 (40%)
		Interaction with RAB4A	616..624		1/7 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920