DRSC/TRiP Functional Genomics Resources

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Protein Alignment ine and SLC6A1

DIOPT Version :9

Sequence 1:NP_001162871.1 Gene:ine / 33659 FlyBaseID:FBgn0011603 Length:943 Species:Drosophila melanogaster
Sequence 2:NP_001335179.1 Gene:SLC6A1 / 6529 HGNCID:11042 Length:599 Species:Homo sapiens


Alignment Length:598 Identity:233/598 - (38%)
Similarity:365/598 - (61%) Gaps:30/598 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly   285 STDGRKLVIRRVPTTANELFDMVNPQTPPPLGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLA 349
            :|:|.|:...::.|..:|          .|:..|...:.:....:.|...|.:..|..:..|:::
Human     2 ATNGSKVADGQISTEVSE----------APVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMS 56

  Fly   350 CIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALG--QL 412
            |:||::||||||||||:|.|:|||.||:||.:.|....:||..:|.|:||||.   ||.||  :|
Human    57 CVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTS---IGGLGVWKL 118

  Fly   413 CPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINA 477
            .|:|||.|||:.|:||.::.||.|||.::|||.:.||.|.:||..|:|.|||..|:      .|.
Human   119 APMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCF------SNY 177

  Fly   478 SAPDTSRTPSE--EFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYF 540
            |..:|:...|.  ||:|..:.|::.||:.||.:||.|...|..||::|||..||.:..:.||.||
Human   178 SMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYF 242

  Fly   541 TATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFA 605
            :||:|::::|||..|.|||.||.||:.|:..|.:.:|.::.||::||:|.|.|.|:..||:|:..
Human   243 SATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALG 307

  Fly   606 SYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAM 670
            |||.::||:.||::.|..:|..||:..|...||.:|.:|.....::.||...|||:.|:.||:|:
Human   308 SYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAV 372

  Fly   671 AKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLF 735
            .::|.:.|||::||.|||.||::|||..||..:|::.|.:||.::..   .|:.:..||:||.|.
Human   373 TQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNR---RELFIAAVCIISYLI 434

  Fly   736 GMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSC 799
            |:.||.|||||.|:|.|:|:|| ::::||.|.:.::|:||||..|...|:::|.|..|..:.:.|
Human   435 GLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLC 499

  Fly   800 WLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGD 864
            |....|.::..:::.|.:.....|.  |.|.:|.|..|:||:.|..|::.||||....||...| 
Human   500 WSFFTPIIVAGVFIFSAVQMTPLTM--GNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKG- 561

  Fly   865 TFWERIRNTLRPN 877
            :..:||:..::|:
Human   562 SLKQRIQVMVQPS 574

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ineNP_001162871.1 SLC5-6-like_sbd 337..876 CDD:294310 223/543 (41%)
SLC6A1NP_001335179.1 SLC6sbd_GAT1 2..599 CDD:212075 233/598 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 577..599
PDZ-binding 597..599
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0733
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D250396at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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