DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ine and slc6a6b

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_001032750.1	Gene:	slc6a6b / 569098	ZFINID:	ZDB-GENE-030131-3077	Length:	625	Species:	Danio rerio

Alignment Length:	614	Identity:	256/614 - (41%)
Similarity:	373/614 - (60%)	Gaps:	34/614 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 DETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLF 392
            ||.....|:::.||:|:.|:|:..|..|||||||||||:|||:|||.||:||.|.||...:|:.|
Zfish    32 DEAEGKHPQREKWASKLDFLLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFF 96

  Fly   393 MELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWID 457
            :|:::||:|..|.|....:|||:|.|.|.||:|:..|::.||.||:.:.:||.|..|:.|:||..
Zfish    97 LEVALGQFTSEGGITCWEKLCPIFTGIGYASIVIVSLLNIYYIVILAWGLYYLFQCFQPELPWAS 161

  Fly   458 CNNRWNTPDC---WVPQRKGINASAPDTSRT-PSEEFFENKVLQISGGLEYPGMMRWELFACLIC 518
            |||:|||.:|   .:.:.|.:.|:|..|:.| |..||:|..||.||.|:|..|.::|:|..||:.
Zfish   162 CNNKWNTENCVEDTLRRNKTLWAAANATNFTSPVTEFWERNVLSISDGIEEVGHVKWDLALCLLA 226

  Fly   519 AWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVW 583
            .|::.:|..||.:||:.||.|.|||||||::|:|:||.|||.|||||::|:..|..:.|.:..||
Zfish   227 MWVICFFCVWKGVKSTGKVVYVTATFPFVMLIVLLVRGVTLPGAAEGIKFYLYPNVTRLGDPEVW 291

  Fly   584 INAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQN 648
            |:|.:|.|.|..|..|:|.|..|||||..|..||.:.:..:|..||.:.|...||.||.:|.||.
Zfish   292 IDAGTQIFFSYAICLGAMTSLGSYNKYKYNCYRDCLLLGGLNSATSFVSGFAIFSVLGFMAQEQG 356

  Fly   649 TNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRW 713
            .::.||...|||:.|:.||:|:..||....||::||.|||.|||:|||..||..:||:.|.:|.:
Zfish   357 VDIADVAESGPGLAFIAYPKAVTMMPLPTFWAILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSF 421

  Fly   714 IKRHLGY-HEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAWFYG 776
            :::  || .||.:..||.:|.|.|:..:.:||:|.|||.|:|||| |.::::||.:.||:||.||
Zfish   422 LRK--GYRREIFIAIVCFVSYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECIAVAWVYG 484

  Fly   777 TGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWM 841
            .......:::|.|..|:.:::..|.|:.|.|....::.||:.| .|..:|..|.||||:.|:||.
Zfish   485 ADNFYDAIEEMIGYRPNPWMKWSWTVVTPFLCVGCFIFSLVKY-APLRYNKIYEYPDWSIGVGWT 548

  Fly   842 FASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHHCEHDY-PEQEQFMLAQEM 905
            .|..|:||||...||..::|.|... |||:....|     ...|...|..:| |:..:  |||
Zfish   549 LALASMICIPMVVVIKIIQSDGPLI-ERIKAVAAP-----VRGGASSCPQEYQPKSNE--LAQ-- 603

  Fly   906 ATVYKPTNPHLLNLGQKCGYNAMQASPSH 934
                 |.:|:         :|...|.|:|
Zfish   604 -----PLDPN---------WNGGLAKPTH 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	239/544 (44%)
slc6a6b	NP_001032750.1	SLC6sbd_TauT	41..582	CDD:271398	239/544 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920