DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ine and slc6a16b

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_001103944.1	Gene:	slc6a16b / 567809	ZFINID:	ZDB-GENE-070424-95	Length:	676	Species:	Danio rerio

Alignment Length:	622	Identity:	183/622 - (29%)
Similarity:	313/622 - (50%)	Gaps:	103/622 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 PPLGVDDDDSYLDMS---DETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGV 374
            |||..|.....:::.   :....|:..:..|.:|:::.||.:|:||||||||||||:|:::|||.
Zfish     6 PPLPADGQQDEVELRLGLEPEVPLETARDGWDSKVEYFLAQVGFSVGLGNVWRFPYLCHQNGGGA 70

  Fly   375 FLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIG 439
            |::.|.:::.:..:||.|:||:.||...:|.||....:.|...|.|.:|.||.|.::.||:||||
Zfish    71 FILLYVVLMALVGVPLFFLELAAGQSIRQGSIGVWRHISPKLVGIGYSSCVVCFFVALYYNVIIG 135

  Fly   440 YSIYYFFTSFKTEMPWIDCNNRWNT--PDCWVPQRKGINASAPDTSRTPSEEFFENKVLQISGGL 502
            :||:|...||:..:||..|....|:  .:|              .:.:|:..|:..|.|.|:..:
Zfish   136 WSIFYLGNSFQYPLPWEKCPTEGNSTVKEC--------------AASSPTAYFWYRKALDITDSI 186

  Fly   503 EYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLR 567
            :..|...:.|..||:.||::|..|.:|.||||.||.||::.||:|:::..::|.||||||:||::
Zfish   187 DETGEFNFILTGCLLAAWVIVCLAMYKGIKSSGKVMYFSSVFPYVVLLCFLIRGVTLDGASEGIK 251

  Fly   568 FFFRPK---WSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITS 629
            |.|.|:   |::::   ||..||:|.|.:||:.|||:|:::|||..|||..||...||.||.:||
Zfish   252 FMFYPRLEIWADVQ---VWRQAATQVFFALGLGFGSVIAYSSYNPRNNNCHRDAFTVSGVNFMTS 313

  Fly   630 LLVGIFAFSTLG--------------------------------------NLALEQNTN------ 650
            :|..:..|:.||                                      :::|::..|
Zfish   314 VLATLVVFAVLGFRAKTIAAECVKRNLKALLKVTSSAPLPVLSINASDVESISLDEYANWYSTQG 378

  Fly   651 --------------VRDVIGDG---PGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAI 698
                          :.|.:..|   .|:.|:.:.:||...|.:..|:.:||.|||.|||::.|..
Zfish   379 MELSISDYNITACSLEDELRQGVEETGLAFIAFTEAMTLFPGSPFWSALFFLMLLNLGLSTMFGT 443

  Fly   699 VEVVVTSIQDGFPRWIKRHLGYHEIV-VLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMF 762
            :..::|.:.|.|     :.|..|::: .:..|.:..:.|:....:.|.|:..:.|.|:|::.::.
Zfish   444 MAGILTPLTDTF-----KTLRNHKLIFTICSCTVGFVIGLVFTQRCGNYFVTMFDDYSATLPLII 503

  Fly   763 LAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLIN--YHEPTY- 824
            :...|.|:::|.||..|..:::|||..:......:..|..:.|..:..:...||:.  ...|.|
Zfish   504 VVIFQTISVSWVYGADRFLEDLKQMLNRPVPVIYKYLWKFVCPIAMLGLLGASLLKMILKRPEYS 568

  Fly   825 -------HNGRYTYPDWAYGIGWMFASFSLICIP-GY 853
                   ......|||||..:..:....:.:.:| ||
Zfish   569 AWNREKASKEDLPYPDWALAVLIILIIIASLPVPIGY 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	178/595 (30%)
slc6a16b	NP_001103944.1	SLC6sbd-B0AT-like	33..607	CDD:271364	178/595 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910