DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ine and slc6a8

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_001314797.1	Gene:	slc6a8 / 567544	ZFINID:	ZDB-GENE-071024-2	Length:	652	Species:	Danio rerio

Alignment Length:	584	Identity:	242/584 - (41%)
Similarity:	360/584 - (61%)	Gaps:	27/584 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 PRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQ 399
            |.::.|..:|.|:::|:|::|||||||||||:|||:||||||:||.:.:|:..||:.|:|:::||
Zfish    62 PERETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLFIFLGGIPIFFLEIALGQ 126

  Fly   400 YTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNT 464
            :...|.|. :..:.|||||.|.||:|:.|..:|||.:::.:..|||..||...:||..|:|.|||
Zfish   127 FMKAGSIN-VWNIAPLFKGLGYASMVIVFFCNTYYIMVLAWGFYYFIKSFNATLPWSTCDNPWNT 190

  Fly   465 PDCWVPQRKG--------------INASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWELFAC 515
            .:|....|:|              :........|:|..||:|||||.||.||:.||.:.|||..|
Zfish   191 ENCIEIFRQGDCKNGTIGNSTFGNLTCEELANGRSPIIEFWENKVLNISDGLDEPGAVNWELMLC 255

  Fly   516 LICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNA 580
            |:..|:||||..||.:||:.|:.|||||||:|::|||:||.|||.||.:|:.::.:|.||:|..|
Zfish   256 LLAVWVMVYFCVWKGVKSTGKIVYFTATFPYVVLIILLVRGVTLPGAYDGILYYVKPDWSKLGEA 320

  Fly   581 NVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLAL 645
            .|||:|.:|.|.|..|..|::.:..|||::||:..:|...::.:|..||...|...||.||.:|.
Zfish   321 QVWIDAGTQIFFSYAIGLGALTALGSYNRFNNDCYKDAFVLALINSGTSFFAGFVVFSILGFMAS 385

  Fly   646 EQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGF 710
            ||..::..|...|||:.|:.||:|::.||.|.:||.:||.|||.|||:|||..||..||.|.|.|
Zfish   386 EQGVDISKVAESGPGLAFIAYPKAVSMMPVAPVWAALFFIMLLLLGLDSQFVGVEGFVTGILDLF 450

  Fly   711 PRWIKRHLGY-HEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAW 773
            |.  |.::.| .||.|...|::..:..:..:.|||:|.|||.|:|:|| :|:::.||.:.:.:||
Zfish   451 PG--KYYMRYQREIAVAICCLLCFIIDLSMVTQGGMYVFQLFDYYSASGMTLLWQAFWECVVVAW 513

  Fly   774 FYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGI 838
            .||..|...::.:|.|..|..:::.||.::.||:...|::..|:||...||:| .|.||.|...|
Zfish   514 VYGADRFMDDIARMIGYRPFPWMKWCWSIITPCVCMGIFLFHLLNYKPLTYNN-VYVYPWWGEVI 577

  Fly   839 GWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHHCEHDYPEQEQFMLA 902
            ||..|..|::||| .:::..|..:..||.||..|..:|      :.|.||.|:..|:.:...||
Zfish   578 GWCLALSSMLCIP-VSLVYKLSGAKGTFKERWENLTKP------VWGAHHLEYMAPDTDIKSLA 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	233/554 (42%)
slc6a8	NP_001314797.1	SLC6sbd_CT1	64..652	CDD:271397	241/582 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820