DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and slc6a2

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	XP_009301625.1	Gene:	slc6a2 / 565776	ZFINID:	ZDB-GENE-110408-4	Length:	625	Species:	Danio rerio

Alignment Length:	564	Identity:	224/564 - (39%)
Similarity:	337/564 - (59%)	Gaps:	32/564 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 QQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYT 401
            ::.|..||.|:|:.||::|.|.|||||||:|||:|||.||:||.:.|||..:||.:|||::|||.
Zfish    64 RETWGKKMDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYVLFLFIAGMPLFYMELALGQYN 128

  Fly   402 GRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPD 466
            ..| ...|.::||:|||.|...:|::..:..||:|||.:|:||.:.|..:|:||:.|||.||:|:
Zfish   129 REG-AATLWKICPVFKGVGYTVIVIALYVGFYYNVIIAWSLYYLYASLTSELPWLHCNNPWNSPN 192

  Fly   467 CWVPQRKGIN-------ASAPDTSRTPSEEFFENKVLQI--SGGLEYPGMMRWELFACLICAWLM 522
            |..|  |.||       .|......||:.||:|..||..  |.|:...|:.||||..||:....:
Zfish   193 CTEP--KDINGTVLGNGTSYAKYKNTPAAEFYERGVLHSHESKGIGDLGLPRWELTICLVVVAFI 255

  Fly   523 VYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAA 587
            :||:.||.:|||.||.|.|||.|::::::|::|.:||.||..|:|.:......:|.|..|||:||
Zfish   256 LYFSLWKGVKSSGKVVYITATMPYIVLLVLLIRGITLPGAMNGIRAYLHIDLKKLNNPQVWIDAA 320

  Fly   588 SQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVR 652
            :|.|.|||..||.:|:|:||||:|||..||.:..|.:|.:||...|...||.||.:|.:...|::
Zfish   321 TQIFFSLGAGFGVLIAFSSYNKFNNNCYRDAILTSTINCVTSFFSGFAIFSVLGYMAEQHKVNIK 385

  Fly   653 DVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRH 717
            ||..:|.|::||:||:|::.:|.|..:|::||.|||.||::|....:|.|:|.:.|.| :.:||:
Zfish   386 DVATEGAGLVFVIYPEAISTLPGATFFAIVFFIMLLTLGIDSSMGGMEAVLTGLSDDF-KILKRN 449

  Fly   718 ---LGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGR 779
               ..:..:|..|:..:.|      :..||||...|:|.|||..:|:|....:.|.::||||..|
Zfish   450 RKLFTFATVVGTFLMALLC------VTNGGIYVLTLLDKYAAGTSILFGVLFEAIGVSWFYGVDR 508

  Fly   780 LSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFAS 844
            .|:::::|.|..|..|.|.||..:.|..|..:.:.|::.....||  ..|.:|.||..:||..|.
Zfish   509 FSEDIERMMGFKPGIYWRLCWKFVSPAFLLLVVIASIVTSGRLTY--DEYVFPYWADMLGWSIAL 571

  Fly   845 FSLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHH 888
            .|::.:|.||:..|. |...:|.||:...:.|.       .|||
Zfish   572 SSMLFVPFYAIYKFF-SVPSSFKERLAYCVTPE-------HEHH 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	220/550 (40%)
slc6a2	XP_009301625.1	SLC5-6-like_sbd	64..623	CDD:294310	224/564 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920