DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and si:ch211-132b12.6

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_001038523.1	Gene:	si:ch211-132b12.6 / 564583	ZFINID:	ZDB-GENE-050420-179	Length:	577	Species:	Danio rerio

Alignment Length:	527	Identity:	215/527 - (40%)
Similarity:	329/527 - (62%)	Gaps:	21/527 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 WANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRG 404
            |..|.:|:||..|..|||||||||||:||::||||||:||.:.:..|.:||..:|.::||:|..|
Zfish    14 WGKKAEFLLAVAGNVVGLGNVWRFPYLCYRNGGGVFLIPYLVFVVTCGLPLFLLETAMGQFTHEG 78

  Fly   405 PIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWV 469
            .|....:||||.:|.|.|..:.......||::|:.::::|..:||.:::||:.|||.|||.:|
Zfish    79 GITCWHRLCPLAQGVGYAGQLTVLYSCMYYTIILAWALFYLVSSFSSQLPWVSCNNIWNTDNC-- 141

  Fly   470 PQRKGINASAPD---------TSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYF 525
                 :|.:|.:         .|.:.:.||:|.:||.:|||:|..|.:.||:..|||..|::.||
Zfish   142 -----VNLAAGNLTFNRTTLANSTSAATEFWERRVLSLSGGIEDIGKINWEILLCLIAMWIICYF 201

  Fly   526 ATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQN 590
            ..||.:||:.||.|||||||:|::::|::|.:||.||.:|:.|:..|:.:.|.:..||:.|.:|.
Zfish   202 CIWKGVKSTGKVVYFTATFPYVMLLVLLIRGLTLPGALQGVVFYLYPEPARLADPQVWMEAGTQV 266

  Fly   591 FNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVI 655
            |.|..:..|.:||..|||:|:||..||:..:..:|..||.:.|...||.||.:|..|...|.:|.
Zfish   267 FFSYSVCSGILISLGSYNQYSNNCYRDSFWLCLLNSGTSFVAGFAVFSVLGFMAHVQGVPVEEVA 331

  Fly   656 GDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGY 720
            ..|||:.|:.||||||.||:.|||||.||.|::.|||:|||..:|.|:||:.|.||. :.|..|.
Zfish   332 ESGPGLAFIAYPQAMAMMPFPQLWAVCFFIMIILLGLDSQFVGIECVITSVMDLFPE-VLRRAGR 395

  Fly   721 HEIVVLFVCVISCLFG-MPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAWFYGTGRLSKN 783
            .|:.||.:| ::|.|| :..:.:||:|.|||.|:||.: ..::||:..:.:||.|.:|..::...
Zfish   396 RELFVLLLC-LTCFFGQLIMVTEGGMYVFQLFDNYACNGACLLFLSVFESLAIGWLFGAEKMFDI 459

  Fly   784 VKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLI 848
            ::.||...|:::...||..|.|.:....:|.|::.| .|...|..|.||||||.:||:.|..|::
Zfish   460 IEDMTESRPNYWFMLCWKYLTPLVSLMSFVYSMVRY-TPLTFNRWYVYPDWAYALGWLLALSSIL 523

  Fly   849 CIPGYAV 855
            .:||:|:
Zfish   524 LVPGWAL 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	215/527 (41%)
si:ch211-132b12.6	NP_001038523.1	SLC6sbd-TauT-like	11..550	CDD:271387	215/527 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920