DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ine and si:ch211-225b11.1

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_001103931.1	Gene:	si:ch211-225b11.1 / 561694	ZFINID:	ZDB-GENE-060531-39	Length:	609	Species:	Danio rerio

Alignment Length:	561	Identity:	275/561 - (49%)
Similarity:	377/561 - (67%)	Gaps:	14/561 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 DMSDETAQLKPRQQ------HWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIIL 383
            |.::.|...|..||      .|..:::||||.|||:|||||||||||:||:||||.||:||.|:|
Zfish    36 DRAEATRLAKVEQQAAEPRETWGRRLEFVLATIGYAVGLGNVWRFPYLCYRSGGGAFLIPYMIML 100

  Fly   384 FICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTS 448
            |:|.|||||||.:|||||..||:.||.|:||||||.|||:||:|:::.|||:|::.:::||...|
Zfish   101 FLCGIPLLFMEFTVGQYTRLGPVHALAQICPLFKGVGLATVVISYVLCTYYNVLMTWALYYLLHS 165

  Fly   449 FKTEMPWIDCNNRWNT-PDCWVPQRKGINASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWEL 512
            |...:||..|||.||| .:|    ..|...:|... ::.|::||::|||:::.|:|..|.:||||
Zfish   166 FSPSLPWQSCNNTWNTVANC----STGFPGNATHL-QSASQQFFDHKVLEMTSGIERAGGVRWEL 225

  Fly   513 FACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSEL 577
            |..|:.||.:|||..:|.:||:.||.|||||||:.::..|:|..|.|.||..|:.||..|.||:|
Zfish   226 FGLLVLAWGIVYFCIFKGVKSTGKVVYFTATFPYFILFALLVNNVQLPGAKNGILFFLMPNWSKL 290

  Fly   578 KNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGN 642
            ....||:|||:|.|||:||:||||||.||||||||||||||..||..|..||::.|...||.:|.
Zfish   291 LEVQVWVNAAAQIFNSIGISFGSMISMASYNKYNNNILRDTFIVSLANSATSIVAGFVIFSAIGY 355

  Fly   643 LALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQ 707
            :|...|..|.|:..||||::|||||:..:.||.:||||.:||.|||||||:||||:|||.||.|.
Zfish   356 MAHIHNLPVDDIATDGPGLVFVVYPEVFSTMPVSQLWAPLFFIMLLCLGLDSQFAMVEVAVTFIM 420

  Fly   708 DGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIA 772
            |||.|...:.....|::||.||....|.|:|:|.:||||.|||||||.|.|::|||||.:::|:.
Zfish   421 DGFGRKALKVFKRKELIVLAVCSFGFLLGIPHITRGGIYVFQLMDHYTAVVSLMFLAFFEVLAVT 485

  Fly   773 WFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYG 837
            ..:|..|||..|:.|.||.|:.:.|.||..|.|.|:..|.:.|::.| .|..:...||||.||..
Zfish   486 LIFGVKRLSVMVENMLGKKPNLFFRICWQYLSPMLVLGILISSIVQY-TPARYGKSYTYPLWAEL 549

  Fly   838 IGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPNI 878
            :||..:..|:|.|| ...::.|.::..:..:|::.::.|.:
Zfish   550 LGWFISLVSIIWIP-LGALHELWTTEGSLLQRLKKSITPTV 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	271/545 (50%)
si:ch211-225b11.1	NP_001103931.1	SLC5-6-like_sbd	54..587	CDD:294310	269/539 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	559	1.000	Domainoid score	I236
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H76482
Inparanoid	1	1.050	562	1.000	Inparanoid score	I1051
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25739
orthoMCL	1	0.900	-	-		OOG6_109184
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X8703
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970