DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and slc6a22.2

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	XP_005166102.1	Gene:	slc6a22.2 / 561024	ZFINID:	ZDB-GENE-030616-628	Length:	608	Species:	Danio rerio

Alignment Length:	544	Identity:	229/544 - (42%)
Similarity:	338/544 - (62%)	Gaps:	6/544 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 PRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQ 399
            |.::.||||::|:||..|:.:||||||||||:|||:|||.|.|||.:.||.|.|||.|:|.|:||
Zfish    26 PAREQWANKLEFLLAVAGHIIGLGNVWRFPYLCYKNGGGAFFVPYVLFLFTCGIPLFFLETSLGQ 90

  Fly   400 YTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNT 464
            :|.:|.|....::||||:|.|..|.||......||.:|:.::..|.|:||.:|:||..|||.|||
Zfish    91 FTSQGGITCWRKICPLFEGLGFGSQVVVLYTGVYYIIILAWAFLYLFSSFTSELPWASCNNYWNT 155

  Fly   465 PDCWVPQRKGINASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWK 529
            |.|.......|...:|:.:.:|..||:|.::|.:|||:|..|.:||:|..||:.||::.||..||
Zfish   156 PSCMEFSESNITEYSPNKTTSPVIEFWERRILGLSGGIEQIGNVRWDLALCLLLAWIICYFCVWK 220

  Fly   530 SIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSL 594
            .:||:.||.|||||||::::|:|:||.:||.||..|:.|:..|..|.||:..||::|.||.|.|.
Zfish   221 GVKSTGKVVYFTATFPYLMLIVLLVRGLTLPGAINGITFYLYPDPSRLKDPQVWMDAGSQIFYSY 285

  Fly   595 GITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGP 659
            |:..|.:.:..|||||:||..||.|.:..:|.:||.:.|...||.||.:|.||..::..|...||
Zfish   286 GVCTGVLTALGSYNKYDNNCYRDCVYLCLLNSLTSFVAGFAIFSVLGFMADEQGVDISLVAESGP 350

  Fly   660 GMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGY-HEI 723
            |:.|:.||:|:|.||..||||:.||.|::.|||:|:|...|.:||||.|.:|.:.:  :|: .:.
Zfish   351 GLAFIAYPRAVALMPLPQLWAIFFFIMIIFLGLDSEFVYQEALVTSISDMYPSFFQ--VGHRRKF 413

  Fly   724 VVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAWFYGTGRLSKNVKQM 787
            ::||:|..|...|:..:.:||:|.|||.|:||.| :|::..|..|.|.:.|.||..|....|:.|
Zfish   414 LLLFICSASFFVGLLMVTEGGLYVFQLFDYYACSGMTLLTFAILQSICVGWVYGADRHYDCVEDM 478

  Fly   788 TGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPG 852
            .|..|..:::.||..|.|.:....::.||:.| .|...|..|.||.|.|.||..|...|.:.:|.
Zfish   479 IGYRPWPFMKCCWKYLTPAICTGTFIFSLVQY-TPLKFNNEYEYPWWGYAIGGFFTLSSTLLVPL 542

  Fly   853 YAVINFLRSSGDTFWERIRNTLRP 876
            : :|..:.::..:..:|:|....|
Zfish   543 W-MIYLVGTTPGSMRQRVRALCTP 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	227/540 (42%)
slc6a22.2	XP_005166102.1	SLC6sbd-TauT-like	28..565	CDD:271387	227/540 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820