Protein Alignment ine and SLC6A15

DIOPT Version :10

• Sequence 1: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_877499.1
• Gene: SLC6A15 / 55117
• HGNCID: 13621
• Length: 730
• Species: Homo sapiens
• Alignment Length: 686
• Identity: 210/686 - (30%)
• Similarity: 338/686 - (49%)
• Gaps: 133/686 - (19%)

  Fly   267 QIYSDVT-SVRSLASIGIGSTDGRKLVIRRVPTTANELFDMVNPQTPPPLGVDDDDSYLDMSDET 330
            ::..||| ||:.|.|....:.|..|        |:..:.|          |.::.|:.::...|.
Human    11 ELDDDVTESVKDLLSNEDAADDAFK--------TSELIVD----------GQEEKDTDVEEGSEV 57

  Fly   331 AQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMEL 395
            ...:|.   |.:|:|::||.:|:||||||||||||:|.|:|||.:|:||.|:|.:..|||.|:||
Human    58 EDERPA---WNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLEL 119

  Fly   396 SVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDC-- 458
            ||||...||.||....:.|...|.|.||.||.:.::.||:||||:|::||..||:..:||..|
Human   120 SVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPL 184

  Fly   459 -NNRWNT---PDCWVPQRKGINASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICA 519
             .|..:|   |:|              ...:.:..::..:.|.||..:...|.:.|::..||:.|
Human   185 VKNASHTFVEPEC--------------EQSSATTYYWYREALNISSSISESGGLNWKMTICLLAA 235

  Fly   520 WLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWI 584
            |:||..|..|.|:||.|:.||::.||:|::|..::||..|:|:.:|:|..|.||...:....||.
Human   236 WVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWR 300

  Fly   585 NAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLA----- 644
            .||:|.|.:||:.||.:|:|:||||.:||...|.|.||.:|..||:|..:..|:.||..|
Human   301 EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINE 365

  Fly   645 --LEQNTN--------------------------------VRDVIG------------------- 656
              :.||:.                                |.|:|.
Human   366 KCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEE 430

  Fly   657 ------DGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIK 715
                  .|.|:.|:.:.:||...|.:..|:||||.||:.|||.|.|..:|.:||.|.|.|.  ::
Human   431 ELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFK--VR 493

  Fly   716 RHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRL 780
            :     ||:.:..|:::...|:..:.:.|.|:..:.|.|:|::.::.:...:.||:.:.||..:.
Human   494 K-----EILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKF 553

  Fly   781 SKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLIN--YHEPTYH--------NGRYTYPDWA 835
            .:::|.|.|.|||.|....|..:.|.:|.::.:.|::|  ...|.|:        ....:||.|.
Human   554 MEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWG 618

  Fly   836 YGIGWMFASFSLICIPGYAVINFLR-------SSGD 864
            ..:......|:::.:|   |:..:|       |||:
Human   619 LVVCVSLVVFAILPVP---VVFIVRRFNLIDDSSGN 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	195/615 (32%)
SLC6A15	NP_877499.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	41..60		4/28 (14%)
		SLC6sbd_SBAT1	61..640	CDD:212091	192/605 (32%)