Protein Alignment ine and Slc6a8

DIOPT Version :10

• Sequence 1: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_059044.1
• Gene: Slc6a8 / 50690
• RGDID: 619711
• Length: 635
• Species: Rattus norvegicus
• Alignment Length: 614
• Identity: 240/614 - (39%)
• Similarity: 363/614 - (59%)
• Gaps: 38/614 - (6%)

  Fly   301 NELFDMVNPQTPPPLGVDDDDSYLDMSDETAQL--------KPRQQHWANKMQFVLACIGYSVGL 357
            |.::.:...:...||.|...|......|..|.|        .|.::.|..:|.|:::|:|::|||
  Rat     8 NGIYSVSGDEKKGPLIVSGPDGAPSKGDGPAGLGAPSSRLAVPPRETWTRQMDFIMSCVGFAVGL 72

  Fly   358 GNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLA 422
            ||||||||:|||:||||||:||.:|..:..||:.|:|:|:||:...|.|. :..:||||||.|.|
  Rat    73 GNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSIN-VWNICPLFKGLGYA 136

  Fly   423 SVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKG--INASAPDTS-- 483
            |:|:.|..:|||.:::.:..||...||.|.:||..|.:.||||||....|..  .|||..:.:
  Rat   137 SMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCD 201

  Fly   484 -----RTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTAT 543
                 |:|..||:|||||::|.|||.||.:.||:..||:..|::|||..||.:||:.|:.|||||
  Rat   202 QLADRRSPVIEFWENKVLRLSTGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTAT 266

  Fly   544 FPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYN 608
            ||:|::::|:||.|.|.||.:|:.::.:|.||:|.:..|||:|.:|.|.|..|..|::.:..|||
  Rat   267 FPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYN 331

  Fly   609 KYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKM 673
            ::|||..:|.:.::.:|..||...|...||.||.:|.||..::..|...|||:.|:.||:|:..|
  Rat   332 RFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYPRAVTLM 396

  Fly   674 PYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYH-----EIVVLFVCVISC 733
            |.|.|||.:||||||.|||:|||..||..:|.:.|..|      ..|:     ||.|...|.:..
  Rat   397 PVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLP------ASYYFRFQREISVALCCALCF 455

  Fly   734 LFGMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLR 797
            :..:..:..||:|.|||.|:|:|| .|:::.||.:.:.:||.||..|...::..|.|..|..:::
  Rat   456 VIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMK 520

  Fly   798 SCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSS 862
            .||....|.:...|::.::: |::|..:|..|.||.|...:||.||..|::|:|.:.:...||:.
  Rat   521 WCWSFFTPLVCMGIFIFNVV-YYKPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAK 584

  Fly   863 GDTFWERIRNTLRPNIYECKICGEHHCEH 891
            | |..||.::..:|      |.|.||.|:
  Rat   585 G-TMAERWQHLTQP------IWGLHHLEY 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	225/553 (41%)
Slc6a8	NP_059044.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		8/38 (21%)
		SLC6sbd_CT1	52..621	CDD:271397	231/570 (41%)