Protein Alignment ine and Slc6a12

DIOPT Version :10

• Sequence 1: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_059031.1
• Gene: Slc6a12 / 50676
• RGDID: 620255
• Length: 628
• Species: Rattus norvegicus
• Alignment Length: 564
• Identity: 235/564 - (41%)
• Similarity: 359/564 - (63%)
• Gaps: 8/564 - (1%)

  Fly   317 VDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCI 381
            |.::...:|..|:. |:|.|.| |.|||:|||:..|..:||||||||||:|||:|||.|.:||.|
  Rat    32 VPEEGEMMDQKDKD-QVKDRGQ-WTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFI 94

  Fly   382 ILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFF 446
            ..|.|.||:.|:|:::|||:.:|.:.|..::|||.:|.|:||||:...::.||.:|:.::::|.|
  Rat    95 FFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLF 159

  Fly   447 TSFKTEMPWIDCNNRWNTPDC--WVPQRKGINASAPDTSRTPSEEFFENKVLQISGGLEYPGMMR 509
            :||..|:||..|.|.|||..|  ::.......||..:...:|..||:|.:||.|:.|:...|.:|
  Rat   160 SSFTWELPWTTCTNSWNTEHCVDFLNYSSTRAASYSENFTSPVMEFWERRVLGITSGIHDLGSLR 224

  Fly   510 WELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKW 574
            |||..||:.||::.||..||.:||:.||.|||||||::::|||::|.|||.||.:|:.|:.:|..
  Rat   225 WELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDL 289

  Fly   575 SELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFST 639
            ..||:..||::|.:|.|.|..|..|.:.:..|||||:||..||::|:..:|..||.:.|...||.
  Rat   290 LRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSI 354

  Fly   640 LGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVT 704
            ||.:|.||...:.:|...|||:.|:.:|:|:..||.:|||:.:||.|||.|||:|||..:|.:||
  Rat   355 LGFMAQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFLMLLFLGLDSQFVCMECLVT 419

  Fly   705 SIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQM 768
            :..|.||:.:::. |..|:::|.|.::..|.|:..:.:||:|.|||.|:||:| :.::||:..::
  Rat   420 ASMDMFPQQLRKR-GRRELLILAVAIVCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEV 483

  Fly   769 IAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPD 833
            |.|.|.||..|...||:.|.|..|...::..||.|.|.|..|.:..||..| .|..:|..|.||.
  Rat   484 ICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKY-TPLKYNNVYIYPS 547

  Fly   834 WAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPN 877
            |.|.|||:.|..|:.|:|.:.:|..|::.| :|.:|::..:.|:
  Rat   548 WGYSIGWLLAFSSMACVPLFIIITLLKTQG-SFKKRLQRLITPD 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	228/541 (42%)
Slc6a12	NP_059031.1	SLC5-6-like_sbd	49..589	CDD:444915	229/543 (42%)