DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and RGD1562492

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_001102616.1	Gene:	RGD1562492 / 499151	RGDID:	1562492	Length:	743	Species:	Rattus norvegicus

Alignment Length:	603	Identity:	159/603 - (26%)
Similarity:	254/603 - (42%)	Gaps:	120/603 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 ANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGP 405
            |.|.:.:|..:.:|:|||:.|||||:|:::|||.||:.|.|:|.:..|||::||:.:||:.....
  Rat    53 AKKTENILILVAFSIGLGSTWRFPYLCHQNGGGSFLLMYLILLLLLGIPLMYMEMVIGQWLRVDN 117

  Fly   406 IGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVP 470
            |.|...|.|...|.|.:|::...|:..|.|.::.:|::|...||....||.:|           |
  Rat   118 IRAWKHLVPWLSGVGYSSMLACALVILYNSALVSWSLFYLGQSFDYPTPWENC-----------P 171

  Fly   471 QRKGINASAPDTSRT-PSEEFFENKVL----QISGGLEYPGMMRWELFACLICAWLMVYFATWKS 530
            ..|..:.|.....|| |.:.|:.:.||    ||..|:|   ::...:..||...|..:|......
  Rat   172 LVKNFSTSDISCLRTEPHQFFWYHTVLRASDQIEEGIE---VLVLNVTLCLFATWFFLYITMVTR 233

  Fly   531 IKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLG 595
            ||.|..:..|:..||.||:.........:.|..:.|:.....:.|.|.:.:.|..|......|||
  Rat   234 IKISVLMMIFSILFPNVLLFCFFTHIFFVKGVRDSLKRLVTTELSILASLDAWRQAGGHVLYSLG 298

  Fly   596 ITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTL-------GNLALEQNT---- 649
            :..|::|:|:||.....|.::....|:.||::||||.....|..|       |...:|.|.
  Rat   299 LGMGTIITFSSYQTRGENYIKWASFVAMVNLMTSLLSSSVIFLMLGFWIENSGTPCVESNVSNLL 363

  Fly   650 -----------------------------------NVRDVIG----------------DGPGMIF 663
                                               |:|:.:.                :|||:.:
  Rat   364 SLIANGVLPQVAWPPKDIIHRSPLEYLDWISQLPKNIRNEVAHFTLPCSILVQKEKFMEGPGLAY 428

  Fly   664 VVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFV 728
            |.:.||:...|.:..||::||..|:.:||.:...:||.:..|:|..... :::|       ...|
  Rat   429 VAFSQAITLFPGSSFWAIIFFMSLVIMGLGTMTTLVEGIALSLQKSIST-LEKH-------PKLV 485

  Fly   729 CVISCLFGMPNII-----QGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMT 788
            .||.||.|....:     .|....|...||....|.||.:|| |.:::||.||..|....:....
  Rat   486 PVIICLGGFLGSLVFSSRPGSYVVFLFDDHLVPMVLIMIVAF-QNLSLAWVYGIKRFRAEMFGQL 549

  Fly   789 GK---APSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDW-------------AYG 837
            |:   ||..:|.|...:....:|..|:.|:|       |.:...:|..|             ...
  Rat   550 GRLVWAPFTFLWSYVTLPTLLVLLTIYFLNL-------YFSESLSYVSWNNSMSQEVKQPYQRIA 607

  Fly   838 IGWM-FAS-FSLICIPGY 853
            :||: |.| .:|:.||.|
  Rat   608 LGWVTFLSVLALLPIPMY 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	159/603 (26%)
RGD1562492	NP_001102616.1	SLC5-6-like_sbd	50..621	CDD:382020	156/597 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820