DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ine and slc6a5

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_001009557.1	Gene:	slc6a5 / 494450	ZFINID:	ZDB-GENE-050105-2	Length:	786	Species:	Danio rerio

Alignment Length:	806	Identity:	275/806 - (34%)
Similarity:	421/806 - (52%)	Gaps:	127/806 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 QPGQVLANQPTAAVSTSTVTFTIDDCNEEGDAIPAAASVPAPVTMPAISPTPAT---LTCTTTTT 184
            ||...:..||:                  |..:.|..:.....:.||..|.|..   ..|.:..
Zfish    12 QPSNSVPPQPS------------------GGPVGATTNTKPENSKPAPPPPPVNERKTFCPSEN- 57

  Fly   185 MAGDSVAVSPLSMELKSRLGSHHSSMRSVVSGYLPG----------LSDSSGNLVGGVSMATSGL 239
                    .|..||.....|:..::        .||          ..||.|.:......|||..
Zfish    58 --------KPCDMEANKAYGTFKNT--------APGPTFAGVNSAVRKDSVGKMDASTGKATSDF 106

  Fly   240 QAPNPLYMQPQASLSGSSYHFHELAGNQIYSDVTSVRSLASIGIGSTDGRKLVIRRVPTTANELF 304
            .:.|      |:::..::.|      |....|.||: |..:|.:| |||...|:   |.|.
Zfish   107 MSNN------QSAVRIAAEH------NNSTGDWTSM-SQTTIILG-TDGNTSVL---PGTV---- 150

  Fly   305 DMVNPQTPPP------LGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRF 363
                  |.||      |..||||.  |..||.   |.| .:|:||:.|:|:.:||:|||||||||
Zfish   151 ------TGPPTDDTGRLFQDDDDD--DGGDEN---KAR-GNWSNKLDFILSMVGYAVGLGNVWRF 203

  Fly   364 PYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSF 428
            ||:.:::|||.||:||.|:|.:..||:..:|:|:||:..:||: ::.:..|..:|.|:|.:::|.
Zfish   204 PYLAFQNGGGAFLIPYLIMLGLAGIPIFLLEVSLGQFASQGPV-SVWKAIPALQGCGIAMLIISV 267

  Fly   429 LMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQ---------------------- 471
            |::.||::|:.:::||.|.|.|..:||..|.|.|||.:|....
Zfish   268 LIAIYYNIIMCWTLYYLFASLKETLPWATCKNEWNTVECKDKDMLLLDTCILRDRNITSIKNTTF 332

  Fly   472 ----------RKGINASAPD-TSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYF 525
                      .|.:|.:..: |..:||||:|:..||.||.|:||||.:||.|.|||..|||:||.
Zfish   333 CLSANVVGNLSKLLNVTVDNKTYVSPSEEYFKYNVLHISKGIEYPGDIRWPLAACLFLAWLIVYA 397

  Fly   526 ATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQN 590
            :..|.||||.||.|||||||:|:::||::|.|||.||..|:.:|..|||.:|.:|.||.:||:|.
Zfish   398 SLAKGIKSSGKVVYFTATFPYVVLVILLIRGVTLPGAGSGILYFITPKWEKLNDAKVWKDAATQI 462

  Fly   591 FNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVI 655
            |.||...:|.:|:.:||||::||..|||:.|:..|..||:..|...||.:|.:|.|....:..|.
Zfish   463 FFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAHELKVPIESVA 527

  Fly   656 GDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGY 720
            .:|||:.|||||:|:.::|.:..||::||.|||.|||::.||.:|.:|||:.|.||:::::|...
Zfish   528 DEGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSVSDEFPKYLRKHKPQ 592

  Fly   721 HEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVK 785
            ..:|   .|:...:.|.|.|.:.|:|..||:|.:|||.:::.:|..:::.|::.||..|..::::
Zfish   593 FTLV---CCLSFFVLGFPMITESGMYMLQLVDTFAASYSLVIIAIFELVGISYIYGLQRFCEDIE 654

  Fly   786 QMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICI 850
            .|.|..|:.:.|.||..:.|.:|..|..|||..:...||.:  ||||:|:..:||:....|:|.|
Zfish   655 MMIGFQPNKFWRVCWAFVTPTILTFILALSLYQWKVMTYED--YTYPNWSMVLGWLMVICSVIWI 717

  Fly   851 PGYAVINFLRSSGDTFWERIRNTLRP 876
            |....|....:.|... ||::....|
Zfish   718 PIMFAIKMHLAPGSLI-ERLKLVCSP 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	222/571 (39%)
slc6a5	NP_001009557.1	SLC5-6-like_sbd	177..775	CDD:294310	224/574 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820