DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and CG4476

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	195/577 - (33%)
Similarity:	319/577 - (55%)	Gaps:	45/577 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 SYLDMSDETAQLKP---RQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIIL 383
            |.|.|:.|:::|.|   .:.:|.:.::|:::||..|||||||||||:...::|||.||:||.::|
  Fly    33 SLLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVL 97

  Fly   384 FICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTS 448
            |:...|:.:||:.:||::.|| |..:....||.:|.|.|.::...:::|||:.::..::.|||.|
  Fly    98 FVVGKPIYYMEMLLGQFSSRG-IVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDS 161

  Fly   449 FKTEMPWIDCNNRWNTPDCWV------PQRKGINASAPDTSRTPSEEFFENKVLQISGGLEYPGM 507
            |.:|:||..|...|.  |..|      |.:..::.:...:::...:....|:...:..|:.||.
  Fly   162 FASELPWSFCREEWG--DGCVSASGGQPLQGQLSRNFSSSTQLYLQRIVLNETDSLEEGIGYPS- 223

  Fly   508 MRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRP 572
              ..|...|..:||.|.....:.:|||.|..|..|.||:|::.||:|||:||.||.:|:.:|..|
  Fly   224 --GSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTP 286

  Fly   573 KWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAF 637
            :|.:|....||.||.:|.|.||.:.||.:|.::|||::.:|:.||...|:.::..||||.|:..|
  Fly   287 QWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIF 351

  Fly   638 STLGNLALEQNT-NVRDVIGDGPGMIFVVYPQAMAKMP-YAQLWAVMFFFMLLCLGLNSQFAIVE 700
            ..|||||.|..| ::..|:..|||:.|:.||.|:||.. :.|:::::||.||..||:.|...:|.
  Fly   352 GILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVS 416

  Fly   701 VVVTSIQDGFPR---WIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMF 762
            .::|.::|.|..   |         |:|:.:.||..|.|:..|..||.:...|||.:..:...:.
  Fly   417 CIMTVLKDQFVNVKLW---------IIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLV 472

  Fly   763 LAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNG 827
            .|..::||:.|.|||.||.::.:.|.....|.|.|.||.::.|.::..|.|.||:.. .|..:||
  Fly   473 SAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTM-RPLSYNG 536

  Fly   828 RYTYPDWAYGIGWMFASFSLICI-------PGYAVINFLRSSGDTFWERIRNTLRPN 877
            : .:|.....:||..:.    ||       .|||  ||.:..| :...||.|:::|:
  Fly   537 Q-EFPLVYRVVGWCVSG----CIIGQLFYWAGYA--NFKQPKG-SLKSRINNSIKPH 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	188/556 (34%)
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	169/488 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440786
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850