Protein Alignment ine and SLC6A17

DIOPT Version :10

• Sequence 1: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_001010898.1
• Gene: SLC6A17 / 388662
• HGNCID: 31399
• Length: 727
• Species: Homo sapiens
• Alignment Length: 705
• Identity: 219/705 - (31%)
• Similarity: 334/705 - (47%)
• Gaps: 132/705 - (18%)

  Fly   324 LDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSI 388
            ||..|..|        |.:|:|::||.||:||||||:|||||:|.|:|||.:||||.::|.|..|
Human    55 LDAEDRPA--------WNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGI 111

  Fly   389 PLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEM 453
            ||.|:||:|||...||.||....:||...|.|.:|.:|...:..||:||||:||:|||.||:..:
Human   112 PLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPL 176

  Fly   454 PWIDCNNRWNTPDCWVP-QRKG----INASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWELF 513
            ||.:|           | .|.|    :.|....:|.|  ..|:..:.|.||..:...|.:.|::.
Human   177 PWSEC-----------PVVRNGSVAVVEAECEKSSAT--TYFWYREALDISDSISESGGLNWKMT 228

  Fly   514 ACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELK 578
            .||:.||.:|..|..|.|:||.||.||::.||:|::...:||.:.|.||.:|:...|.||..::.
Human   229 LCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKML 293

  Fly   579 NANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLG-- 641
            :..||..||:|.|.:||:.||.:|:|:||||.:||...|...||.:|..||:|..:..|:.||
Human   294 DPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFK 358

  Fly   642 -NLALEQ-------------NTNV--RDVIG---------------------------------- 656
             |:..|:             ||||  ||:|.
Human   359 ANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLD 423

  Fly   657 ------------DGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDG 709
                        .|.|:.|:.:.:||...|.:..|:||||.||:.|||.|....:..:.|.|.|.
Human   424 PCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDT 488

  Fly   710 F--PRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIA 772
            |  |:         |:..:..||.:.|.|:..:.:.|.|:..:.|.|:|::.:..:...:.||:|
Human   489 FKVPK---------EMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVA 544

  Fly   773 WFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLI--NYHEPTYH-------NGR 828
            |.|||.:..:.:.:|.|..|..:....|..:.|..:..:...|:|  ....|.|.       ..|
Human   545 WIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAER 609

  Fly   829 YTY-PDWAYGIGWMFASFSLICIPGYAVIN--FLRSSGDTFWERIRNTLRPNIYECKICGE-HHC 889
            |.| |:||..:.......:.:.||...|:.  .|.|.|.       |||..:..:.::..: .:.
Human   610 YLYFPNWAMALLITLIVVATLPIPVVFVLRHFHLLSDGS-------NTLSVSYKKGRMMKDISNL 667

  Fly   890 EHDYPEQEQFMLAQEMATVYKPTNPHLLNLGQKCGYNAMQASPSHAE-AGGPCGQ 943
            |.:  ::.:|:|::..:....|...|...||        ..|.|..| :|.|.|:
Human   668 EEN--DETRFILSKVPSEAPSPMPTHRSYLG--------PGSTSPLETSGNPNGR 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	202/621 (33%)
SLC6A17	NP_001010898.1	SLC6sbd_NTT4	60..648	CDD:271403	199/617 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..727		10/41 (24%)