DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ine and Slc6a14

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	XP_038955501.1	Gene:	Slc6a14 / 298340	RGDID:	1561810	Length:	646	Species:	Rattus norvegicus

Alignment Length:	616	Identity:	227/616 - (36%)
Similarity:	361/616 - (58%)	Gaps:	51/616 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 DDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILF 384
            ::.::..:||..:    :.:|:.|..::|:.:||:|||||||||||:.|.:|||.||:||.|:|.
  Rat    29 ENFHVGENDENQE----RGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLA 89

  Fly   385 ICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSF 449
            :..:||.|:|.|:||:...||: ::.::.|||:|.|:..|::|..::.||:|||.||:||.|.||
  Rat    90 LAGLPLFFLECSLGQFASLGPV-SVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYLFASF 153

  Fly   450 KTEMPWIDCNNRWNTPDC------------------------WVPQR-----KGINASAPDTSRT 485
            ::.:||.:|::.|...:|                        ||...     .|.....|  .:.
  Rat   154 QSVLPWANCSSSWADDNCSRQPIVTGCRVSTDTGGDMFMNISWVNSNNFTCLNGSEVFRP--GQL 216

  Fly   486 PSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLII 550
            |||::::...|:.|.|::..|::.|.|..||:.||::|..|.:|.||||.||.||||.||:|:::
  Rat   217 PSEQYWDKVTLRRSSGMDETGVIVWYLALCLLLAWIIVGAALFKGIKSSGKVVYFTALFPYVVLL 281

  Fly   551 ILMVRAVTLDGAAEGLRFFF--RPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNN 613
            ||::|..||:||::|:.::.  :..:::|:.|.||.:||:|.|.||.:.:|.:::.:||||:|||
  Rat   282 ILLIRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNKFNNN 346

  Fly   614 ILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQL 678
            ...|.:.|...|.:||:..|...||.||::|......|..|:..|..:.|:.||:|:|::|....
  Rat   347 CYSDAIIVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPF 411

  Fly   679 WAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQG 743
            |:::||||||.|||:||||.:|.:.|:|||.||:.:||   ....:.|..|:|..|.|:..:.|.
  Rat   412 WSILFFFMLLTLGLDSQFASIETITTTIQDLFPKAMKR---MRVPITLGCCLILFLLGLVCVTQA 473

  Fly   744 GIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTG-KAPSFYL--RSCWLVLGP 805
            |||:..|:||:.|...|:..|..::..|.|.||..|..::::.|.| |...|:|  |:||.|:.|
  Rat   474 GIYWVHLIDHFCAGWGILIAAILEIAGIIWIYGGNRFIEDIEMMIGAKRWLFWLWWRACWFVITP 538

  Fly   806 CLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERI 870
            .||.||.|.||:.:|.|.|.:  ..||||...:||....|.:|.||..|:|..:|:.|:.. :||
  Rat   539 ILLSAILVWSLVKFHRPNYAD--IPYPDWGVALGWCMIIFCIIWIPIMAIIKIVRAEGNIL-QRI 600

  Fly   871 RNTLRP----NIYECKICGEHHCEHDYPEQE 897
            ....||    ..|..|..||.:.:...|.:|
  Rat   601 IKCCRPASNWGPYLEKHRGERYKDMAEPAKE 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	217/572 (38%)
Slc6a14	XP_038955501.1	SLC6sbd_ATB0	42..645	CDD:271391	225/599 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820