Protein Alignment ine and Slc6a6

DIOPT Version :10

• Sequence 1: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: XP_008761345.1
• Gene: Slc6a6 / 29464
• RGDID: 61912
• Length: 631
• Species: Rattus norvegicus
• Alignment Length: 620
• Identity: 250/620 - (40%)
• Similarity: 366/620 - (59%)
• Gaps: 50/620 - (8%)

  Fly   328 DETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLF 392
            ||.....|:::.|::|:.|||:..|..|||||||||||:|||:|||.||:||.|.||...:|:.|
  Rat    42 DEADGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFF 106

  Fly   393 MELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWID 457
            :|:.:||||..|.|....::||||.|.|.||:|:..|::.||.||:.::.||.|.||:.::||..
  Rat   107 LEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFQSFQKDLPWAH 171

  Fly   458 CNNRWNTPDC-----------WVPQRKGINASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWE 511
            ||:.||||.|           ||      :.||.:.: :|..||:|..||.:|.|:::||.::|:
  Rat   172 CNHSWNTPQCMEDTLRRNESHWV------SLSAANFT-SPVIEFWERNVLSLSSGIDHPGSLKWD 229

  Fly   512 LFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSE 576
            |..||:..||:.:|..||.::|:.||.||||||||.::::|:||.:||.||.||::|:..|..|.
  Rat   230 LALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPNISR 294

  Fly   577 LKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLG 641
            |::..|||:|.:|.|.|..|..|:|.|..|||||..|..||.:.:..:|..||.:.|...||.||
  Rat   295 LEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILG 359

  Fly   642 NLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSI 706
            .:|.||..::.||...|||:.|:.||:|:..||....|:::||.|||.|||:|||..||..:||:
  Rat   360 FMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSL 424

  Fly   707 QDGFPRWIKRHLGY-HEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMI 769
            .|.:|.::::  || .||.:..||.||.|.|:..:.:||:|.|||.|:|||| |.::::||.:..
  Rat   425 VDLYPSFLRK--GYRREIFIAIVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECF 487

  Fly   770 AIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDW 834
            .|||.||...|...::.|.|..|..:::..|.|:.|.|....::.||:.|...|| |..|.||||
  Rat   488 VIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPALCVGCFIFSLVKYVPLTY-NKVYRYPDW 551

  Fly   835 AYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHHCEHDYPEQEQF 899
            |.|:||..|..|::|||...||...|:.| ....||:..:.|.                 |..::
  Rat   552 AIGLGWGLALSSMVCIPLVIVILLCRTEG-PLRVRIKYLITPR-----------------EPNRW 598

  Fly   900 MLAQEMATVYKPTNPHLLNLGQKCGYNAMQASPSH 934
            .:.:|.||.:. :...|:|       .|:. .|||
  Rat   599 AVEREGATPFH-SRATLMN-------GALM-KPSH 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	236/551 (43%)
Slc6a6	XP_008761345.1	SLC5-6-like_sbd	51..592	CDD:444915	236/551 (43%)