DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ine and Slc6a16

DIOPT Version :9

Sequence 1:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	XP_038949993.1	Gene:	Slc6a16 / 292902	RGDID:	1561338	Length:	850	Species:	Rattus norvegicus

Alignment Length:	788	Identity:	182/788 - (23%)
Similarity:	313/788 - (39%)	Gaps:	146/788 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 PAAASVPAPV-TMPAISPTPATLTCTTTTTMAGDSVAVSPLSMELKSRLGSHHSSMRSVVSGYLP 219
            |....|..|. |.|.::|...:...:........|.|.:....|..|.:.:..||:...||....
  Rat    75 PTKVKVSGPQRTRPKVAPDMRSSKESEDAFFLAKSRASASDRPEESSLVKTSGSSLDKNVSIETT 139

  Fly   220 GLSDSSGNLV---GGVSMATSGLQAPNPLYMQPQASLSGSSYHFHELAGNQIYSDVTSVRSLASI 281
            .||:...||:   .| ::||....|     ...||.:|.|.              |...::..::
  Rat   140 KLSEMDSNLLVWEDG-TLATWSTSA-----WIAQAQVSESR--------------VAKAQAWETL 184

  Fly   282 GIGSTDGRKLVIRRVPTTANELFDMVNPQTPPPLGVDDDDSYLDMSDETAQLKPRQQHWANKMQF 346
            .:.:.....|...:..||  |......|:...|:.::      ..|.|.:.:.|....|::|.::
  Rat   185 ALEAQARGALQFNKPSTT--EYSMETTPKQESPIELN------KTSKENSNVFPPWLLWSSKAEY 241

  Fly   347 VLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQ 411
            :||.:||.|....:.||.......|...|.:.|.::||...|||||:|::|||...:..|.....
  Rat   242 ILALMGYLVMPSGLLRFVTCWVHKGSWSFFIAYLLMLFGLGIPLLFLEMAVGQRAQQSSIDLWKT 306

  Fly   412 LCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGIN 476
            |.|.|.|.|.:.|:|..:.:||.:|...:.::|....|...:||..|           |.:|..:
  Rat   307 LSPWFGGLGYSMVMVCLITNTYLNVFNSWILFYMSHIFHFVVPWDRC-----------PLQKNSS 360

  Fly   477 ASAPDTSRTPSEEFF-ENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYF 540
            ...|:..:..|..:| ..:.|:.|..:|..|...:.|...|..||.::.......|||..||...
  Rat   361 DFDPECEQATSYTYFWYRQTLKASDSIEDGGQPSFNLAMFLFLAWCLICVFMVNGIKSLGKVLCV 425

  Fly   541 TATFPFVLIIILMVRAVTL-DGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISF 604
            ....|:.:||..:||.::: :|...||.:....:.:.:.:..:|..|..|....:|:.||.:||.
  Rat   426 LLQVPYFIIICFLVRTLSMGNGIGYGLNYLLILEVARISDLTMWCQAGIQVLFDIGLGFGPVISL 490

  Fly   605 ASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLA-------LEQNTN------------ 650
            :|:....||.|:|...:....::|.|:...|..|.||..|       .::|||
  Rat   491 SSHMSDFNNCLKDAFLMGLFKIVTLLITTPFFLSILGFWATITTHHCCKKNTNKLLMLIAQGILP 555

  Fly   651 --------------------------VRDV----------------IGDGPGMIFVVYPQAMAKM 673
                                      :|..                |.|.|..:|:::.:.::.:
  Rat   556 PEVEPPDLNDDPISIYNSWLNSLPPPLRSAVLSMVPECNIQKQFMRIEDSPRFLFLIFTEVISLL 620

  Fly   674 PYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMP 738
            |.:..|.|:||..||.|||.:....:...:.::||.|| :.:|.   ..::.:.|.:.:.|.|:.
  Rat   621 PGSAFWTVLFFLALLGLGLCTNLMYMLGNILTLQDTFP-FCRRQ---PRLLTVGVSMTTFLCGLI 681

  Fly   739 NIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSF--------- 794
            .|...|||||.|:..|..:|.|:.:..|:.:|:||.||..|...::..:..: |.|
  Rat   682 FIQPSGIYYFSLLSEYWVAVPIITIILCETLAVAWAYGAKRFLADMMALLSR-PIFPGCSWLWRY 745

  Fly   795 ---------YLRSC-WLVLGPCLLFAIWVLS----LINYHEPTYHNGRYTYPDWAYGIGWMFASF 845
                     .|..| :||.|| |::..|..|    ::.|           :|.|:..:....::.
  Rat   746 VSPVVLLGLLLFICIYLVQGP-LVYMAWDSSTSKEVVRY-----------FPMWSLMLIAGLSAV 798

  Fly   846 SLICIPGY 853
            .|:.||.|
  Rat   799 VLMPIPAY 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	146/603 (24%)
Slc6a16	XP_038949993.1	SLC6sbd_NTT5	232..802	CDD:271392	143/597 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920