Protein Alignment ine and Slc6a4

DIOPT Version :9

• Sequence 1: NP_001162871.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_037166.2
• Gene: Slc6a4 / 25553
• RGDID: 3714
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 613
• Identity: 232/613 - (37%)
• Similarity: 358/613 - (58%)
• Gaps: 41/613 - (6%)

  Fly   296 VPTTANELFDMVNP-------QTPPPLGVDDDDSY-LDMSDETAQLKPRQ---QHWANKMQFVLA 349
            |||||    |...|       ...|.....|:.|: :..:..|...:.||   :.|..||.|:|:
  Rat    31 VPTTA----DRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLS 91

  Fly   350 CIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCP 414
            .|||:|.|||:|||||:||::|||.||:||.|:.....|||.:|||::|||...|.|....::||
  Rat    92 VIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICP 156

  Fly   415 LFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINASA 479
            :|||.|.|..:::|.:::||:.||.:::||..:|....:||..|.|.|||.:|       .|..|
  Rat   157 IFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNC-------TNYFA 214

  Fly   480 PDT------SRTPSEEFFENKVLQI--SGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAK 536
            .|.      |.:|:|||:...||||  |.||:..|.:.|:|..|::..:.::||:.||.:|:|.|
  Rat   215 QDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGK 279

  Fly   537 VRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSM 601
            |.:.|||||::::.:|:||..||.||..|:.|:.:|.|.:|....||::||:|.|.|||..||.:
  Rat   280 VVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVL 344

  Fly   602 ISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGD-GPGMIFVV 665
            ::||||||:|||..:|.:..|.||.:||.:.|...|:.||.:|..:|.:|.:|..| ||.::|:.
  Rat   345 LAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFIT 409

  Fly   666 YPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPR-WIKRHLGYHEIVVLFVC 729
            |.:|:|.||.:..:|::||.||:.|||:|.||.:|.|:|::.|.||. |.||    .|..||.|
  Rat   410 YAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKR----REWFVLIV- 469

  Fly   730 VISCLFG-MPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPS 793
            ||:|:.| :..:..||.|...|::.||....::.:|..:.:|::||||..:...:||:|.|.:|.
  Rat   470 VITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPG 534

  Fly   794 FYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINF 858
            ::.|.||:.:.|  ||.::::.......|.....:|.||.|:..:|:.....|:||||.|.:...
  Rat   535 WFWRICWVAISP--LFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRL 597

  Fly   859 LRSSGDTFWERIRNTLRPNIYECKICGE 886
            :.:.| |..|||..::.|.......||:
  Rat   598 ISTPG-TLKERIIKSITPETPTEIPCGD 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	217/552 (39%)
Slc6a4	NP_037166.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..60		9/32 (28%)
		5HT_transport_N	24..64	CDD:397524	10/36 (28%)
		SLC6sbd_SERT	79..615	CDD:271399	216/550 (39%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624		1/7 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920