Protein Alignment ine and Slc6a3

DIOPT Version :9

• Sequence 1: NP_001162871.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_036826.1
• Gene: Slc6a3 / 24898
• RGDID: 3715
• Length: 619
• Species: Rattus norvegicus
• Alignment Length: 598
• Identity: 235/598 - (39%)
• Similarity: 365/598 - (61%)
• Gaps: 35/598 - (5%)

  Fly   316 GVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYC 380
            ||...:|.|....:|......::.|:.|:.|:|:.||::|.|.|||||||:|||:|||.|||||.
  Rat    39 GVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYL 103

  Fly   381 IILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYF 445
            :.:.|..:||.:|||::||:...|..| :.::||:.||.|...:::||.:..:|:|||.::::||
  Rat   104 LFMVIAGMPLFYMELALGQFNREGAAG-VWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYF 167

  Fly   446 FTSFKTEMPWIDCNNRWNTPDCWVPQRKGINASAPDTS----------RTPSEEFFENKVLQI-- 498
            |:||..::|||.|||.||:|:|       .:|.|.::|          .||:.|:||..||.:
  Rat   168 FSSFTMDLPWIHCNNTWNSPNC-------SDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQ 225

  Fly   499 SGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAA 563
            |.|::..|..||:|.|||:...:::||:.||.:|:|.||.:.|||.|:|::..|::|.|||.||.
  Rat   226 SRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAM 290

  Fly   564 EGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMIT 628
            :|:|.:....:..|..|:|||:||:|...|||:.||.:|:|:||||:.||..||.:..:::|.:|
  Rat   291 DGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLT 355

  Fly   629 SLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLN 693
            |...|...||.||.:|.:.|..:|||..||||:||::||:|:|.:|.:..||.:||.|||.||::
  Rat   356 SFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID 420

  Fly   694 SQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASV 758
            |....:|.|:|.:.|.| :.:.||   .|:..|.:.:.:.|..:..:..||||.|.|:||:||..
  Rat   421 SAMGGMESVITGLVDEF-QLLHRH---RELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGT 481

  Fly   759 TIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPT 823
            :|:|....:.|.:|||||..:.|.::|||||:.|:.|.|.||.::.||.|..:.|:|::.:..|
  Rat   482 SILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPP- 545

  Fly   824 YHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHH 888
             |.|.|.:||||..:||:.|:.|:..:|.||...|....| :|.|::...:.|.        :.|
  Rat   546 -HYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPG-SFREKLAYAITPE--------KDH 600

  Fly   889 CEHDYPEQEQFML 901
            ...|..|..||.|
  Rat   601 QLVDRGEVRQFTL 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	223/550 (41%)
Slc6a3	NP_036826.1	SLC6sbd_DAT1	60..613	CDD:212083	229/575 (40%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		10/29 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820